A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans

Aneesh Sivaraman; Dipesh S. Harmalkar; Jiyoon Kang; Yongseok Choi; Kyeong Lee

doi:10.1039/C8OB03102A

A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans

Aneesh Sivaraman, Dipesh S. Harmalkar, Jiyoon Kang, Yongseok Choi, Kyeong Lee

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.

Original language	English
Pages (from-to)	2153-2161
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	17
Issue number	8
DOIs	https://doi.org/10.1039/C8OB03102A
Publication status	Published - 2019

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF 2018R1A5A2023127).

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/C8OB03102A

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abstract = "2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.",

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AU - Sivaraman, Aneesh

AU - Harmalkar, Dipesh S.

AU - Kang, Jiyoon

AU - Choi, Yongseok

AU - Lee, Kyeong

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PY - 2019

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AB - 2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.

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A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans

Abstract

Bibliographical note

ASJC Scopus subject areas

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