A rare manifestation of hypothyroid myopathy: Hoffmann's syndrome

Kang Won Lee, Sun Hwa Kim, Kyoung Jin Kim, Sang Hyun Kim, Hee Young Kim, Byung Jo Kim, Sin Gon Kim, Dong Seop Choi

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)


    Hypothyroid myopathy is observed frequently and the resolution of the clinical manifestations of myopathy following thyroid hormone replacement is well known. However, a specific subtype of hypothyroid myopathy, Hoffmann's syndrome, characterized by increased muscular mass (pseudohypertrophy), proximal muscle weakness, muscle stiffness and cramps, is rarely reported. Herein, we describe a 34-year-old male who presented with proximal muscle weakness and non-pitting edema of the lower extremities. He initially visited the neurology department where he was suspected of having polymyositis. Additional laboratory evaluation revealed profound autoimmune hypothyroidism and elevated muscle enzymes including creatine kinase. The patient was started on levothyroxine treatment and, subsequently, clinical symptoms and biochemical parameters resolved with the treatment. The present case highlights that hypothyroidism should be considered in the differential diagnosis of musculoskeletal symptoms even in the absence of overt manifestations of hypothyroidism. To our knowledge, this is the first case reported in Korea.

    Original languageEnglish
    Pages (from-to)626-630
    Number of pages5
    JournalEndocrinology and Metabolism
    Issue number4
    Publication statusPublished - 2015

    Bibliographical note

    Publisher Copyright:
    © 2015 Korean Endocrine Society.


    • Creatine kinase
    • Hypothyroidism
    • Muscular diseases

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology


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