A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon

David Jesse Sanchez, Daniel Miranda, Vaithilingaraja Arumugaswami, Seungmin Hwang, Adam E. Singer, Ashkon Senaati, Arash Shahangian, Moon Jung Song, Ren Sun, Genhong Cheng

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon.

    Original languageEnglish
    Pages (from-to)2208-2217
    Number of pages10
    JournalJournal of virology
    Volume82
    Issue number5
    DOIs
    Publication statusPublished - 2008 Mar

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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