A reservoir-type oxygen sensor with 2×3 array for measuring cellular respiration levels

Jungil Park; Hyunwook Nam; Sun Young Ahn; Youngmi Kim Pak; James Jungho Pak

doi:10.1016/j.snb.2012.09.037

A reservoir-type oxygen sensor with 2×3 array for measuring cellular respiration levels

Jungil Park, Hyunwook Nam, Sun Young Ahn, Youngmi Kim Pak, James Jungho Pak

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

This paper describes a 2 × 3 reservoir-type oxygen sensor array integrated with Clark-type sensors, heaters, and temperature sensors on a glass substrate. The measured 90% response time of the fabricated sensors from an air-saturated state to a zero-oxygen state was approximately 9.35 s. These oxygen sensors showed good repeatability during 6 consecutive measurements at 300-s intervals, with an output of 108.2 ± 3.15 nA (mean ± standard deviation) for the air-saturated state and 1.33 ± 0.14 nA for the zerooxygen state. In addition, these sensors showed good linearity, with a correlation coefficient of 0.995 and a sensitivity averaging 2.04 A/cm2 M. A LabVIEW-based measurement system was developed for simultaneously measuring the multiple cellular respiration levels from this oxygen sensor array using a voltage supply, an amplifying module, a DMM (digital multimeter), a switch module, and a temperature-sensing module. The measured cellular respiration ratio of the L6 (rat skeletal muscle cells) between the uncoupled oxygen consumption rate and the coupled oxygen consumption rate for this oxygen sensor array was 2.06, which is similar to the 2.23 value obtained from a commercially available system.

Original language	English
Pages (from-to)	913-920
Number of pages	8
Journal	Sensors and Actuators, B: Chemical
Volume	176
DOIs	https://doi.org/10.1016/j.snb.2012.09.037
Publication status	Published - 2013

Bibliographical note

Funding Information:
This work was supported by the Seoul R&BD Program (No. 10920 ), by a National Research Foundation of Korea Grant funded by the Korean Government (No. R01-2006-000-11371-0 ), and by the National Research Foundation of Korea (NRF) through a grant provided by the Ministry of Education, Science and Technology (MEST) in 2009 (Nos. K20902001448-10E0100-03010 , 20100008474 ).

Keywords

Array type
Cellular respiration
Electrochemistry
Oxygen consumption rate
Oxygen sensor

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2012.09.037

Cite this

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title = "A reservoir-type oxygen sensor with 2×3 array for measuring cellular respiration levels",

abstract = "This paper describes a 2 × 3 reservoir-type oxygen sensor array integrated with Clark-type sensors, heaters, and temperature sensors on a glass substrate. The measured 90% response time of the fabricated sensors from an air-saturated state to a zero-oxygen state was approximately 9.35 s. These oxygen sensors showed good repeatability during 6 consecutive measurements at 300-s intervals, with an output of 108.2 ± 3.15 nA (mean ± standard deviation) for the air-saturated state and 1.33 ± 0.14 nA for the zerooxygen state. In addition, these sensors showed good linearity, with a correlation coefficient of 0.995 and a sensitivity averaging 2.04 A/cm2 M. A LabVIEW-based measurement system was developed for simultaneously measuring the multiple cellular respiration levels from this oxygen sensor array using a voltage supply, an amplifying module, a DMM (digital multimeter), a switch module, and a temperature-sensing module. The measured cellular respiration ratio of the L6 (rat skeletal muscle cells) between the uncoupled oxygen consumption rate and the coupled oxygen consumption rate for this oxygen sensor array was 2.06, which is similar to the 2.23 value obtained from a commercially available system.",

keywords = "Array type, Cellular respiration, Electrochemistry, Oxygen consumption rate, Oxygen sensor",

author = "Jungil Park and Hyunwook Nam and Ahn, {Sun Young} and Pak, {Youngmi Kim} and Pak, {James Jungho}",

note = "Funding Information: This work was supported by the Seoul R&BD Program (No. 10920 ), by a National Research Foundation of Korea Grant funded by the Korean Government (No. R01-2006-000-11371-0 ), and by the National Research Foundation of Korea (NRF) through a grant provided by the Ministry of Education, Science and Technology (MEST) in 2009 (Nos. K20902001448-10E0100-03010 , 20100008474 ). ",

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AU - Park, Jungil

AU - Nam, Hyunwook

AU - Ahn, Sun Young

AU - Pak, Youngmi Kim

AU - Pak, James Jungho

N1 - Funding Information: This work was supported by the Seoul R&BD Program (No. 10920 ), by a National Research Foundation of Korea Grant funded by the Korean Government (No. R01-2006-000-11371-0 ), and by the National Research Foundation of Korea (NRF) through a grant provided by the Ministry of Education, Science and Technology (MEST) in 2009 (Nos. K20902001448-10E0100-03010 , 20100008474 ).

PY - 2013

Y1 - 2013

N2 - This paper describes a 2 × 3 reservoir-type oxygen sensor array integrated with Clark-type sensors, heaters, and temperature sensors on a glass substrate. The measured 90% response time of the fabricated sensors from an air-saturated state to a zero-oxygen state was approximately 9.35 s. These oxygen sensors showed good repeatability during 6 consecutive measurements at 300-s intervals, with an output of 108.2 ± 3.15 nA (mean ± standard deviation) for the air-saturated state and 1.33 ± 0.14 nA for the zerooxygen state. In addition, these sensors showed good linearity, with a correlation coefficient of 0.995 and a sensitivity averaging 2.04 A/cm2 M. A LabVIEW-based measurement system was developed for simultaneously measuring the multiple cellular respiration levels from this oxygen sensor array using a voltage supply, an amplifying module, a DMM (digital multimeter), a switch module, and a temperature-sensing module. The measured cellular respiration ratio of the L6 (rat skeletal muscle cells) between the uncoupled oxygen consumption rate and the coupled oxygen consumption rate for this oxygen sensor array was 2.06, which is similar to the 2.23 value obtained from a commercially available system.

AB - This paper describes a 2 × 3 reservoir-type oxygen sensor array integrated with Clark-type sensors, heaters, and temperature sensors on a glass substrate. The measured 90% response time of the fabricated sensors from an air-saturated state to a zero-oxygen state was approximately 9.35 s. These oxygen sensors showed good repeatability during 6 consecutive measurements at 300-s intervals, with an output of 108.2 ± 3.15 nA (mean ± standard deviation) for the air-saturated state and 1.33 ± 0.14 nA for the zerooxygen state. In addition, these sensors showed good linearity, with a correlation coefficient of 0.995 and a sensitivity averaging 2.04 A/cm2 M. A LabVIEW-based measurement system was developed for simultaneously measuring the multiple cellular respiration levels from this oxygen sensor array using a voltage supply, an amplifying module, a DMM (digital multimeter), a switch module, and a temperature-sensing module. The measured cellular respiration ratio of the L6 (rat skeletal muscle cells) between the uncoupled oxygen consumption rate and the coupled oxygen consumption rate for this oxygen sensor array was 2.06, which is similar to the 2.23 value obtained from a commercially available system.

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KW - Electrochemistry

KW - Oxygen consumption rate

KW - Oxygen sensor

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ER -

A reservoir-type oxygen sensor with 2×3 array for measuring cellular respiration levels

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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