A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression

Arup Podder; Seyoung Koo; Jiyeong Lee; Sora Mun; Sabina Khatun; Hee Gyoo Kang; Sankarprasad Bhuniya; Jong Seung Kim

doi:10.1039/c8cc08991d

A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression

Arup Podder, Seyoung Koo, Jiyeong Lee, Sora Mun, Sabina Khatun, Hee Gyoo Kang, Sankarprasad Bhuniya, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Herein, we report a rhodamine-based redox probe (MQR) to visualize cytosolic NADH in the cellular milieu. Its high sensitivity and selectivity allowed it to track the alteration of the NADH level under metabolic perturbation, suggesting its potential as a useful tool to study the association between the NADH level and metabolic abnormalities with clinical significance.

Original language	English
Pages (from-to)	537-540
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	4
DOIs	https://doi.org/10.1039/c8cc08991d
Publication status	Published - 2019

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc08991d

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title = "A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression",

abstract = "Herein, we report a rhodamine-based redox probe (MQR) to visualize cytosolic NADH in the cellular milieu. Its high sensitivity and selectivity allowed it to track the alteration of the NADH level under metabolic perturbation, suggesting its potential as a useful tool to study the association between the NADH level and metabolic abnormalities with clinical significance.",

author = "Arup Podder and Seyoung Koo and Jiyeong Lee and Sora Mun and Sabina Khatun and Kang, {Hee Gyoo} and Sankarprasad Bhuniya and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by SERB, India (ECR/2015/000035), and a CRI project (Grant 2018R1A3B1052702, J. S. K.) of the NRF in Korea. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

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doi = "10.1039/c8cc08991d",

language = "English",

volume = "55",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression

AU - Podder, Arup

AU - Koo, Seyoung

AU - Lee, Jiyeong

AU - Mun, Sora

AU - Khatun, Sabina

AU - Kang, Hee Gyoo

AU - Bhuniya, Sankarprasad

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by SERB, India (ECR/2015/000035), and a CRI project (Grant 2018R1A3B1052702, J. S. K.) of the NRF in Korea. Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - Herein, we report a rhodamine-based redox probe (MQR) to visualize cytosolic NADH in the cellular milieu. Its high sensitivity and selectivity allowed it to track the alteration of the NADH level under metabolic perturbation, suggesting its potential as a useful tool to study the association between the NADH level and metabolic abnormalities with clinical significance.

AB - Herein, we report a rhodamine-based redox probe (MQR) to visualize cytosolic NADH in the cellular milieu. Its high sensitivity and selectivity allowed it to track the alteration of the NADH level under metabolic perturbation, suggesting its potential as a useful tool to study the association between the NADH level and metabolic abnormalities with clinical significance.

UR - http://www.scopus.com/inward/record.url?scp=85059501435&partnerID=8YFLogxK

U2 - 10.1039/c8cc08991d

DO - 10.1039/c8cc08991d

M3 - Article

C2 - 30556071

AN - SCOPUS:85059501435

SN - 1359-7345

VL - 55

SP - 537

EP - 540

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

A rhodamine based fluorescent probe validates substrate and cellular hypoxia specific NADH expression

Abstract

ASJC Scopus subject areas

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