A schiff base fluorescence enhancement probe for Fe(III) and its sensing applications in cancer cells

Na Hee Kim, Junho Lee, Sungnam Park, Junyang Jung, Dokyoung Kim

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We report a new Schiff base fluorescent probe which senses ferric ion, Fe(III), with a significant fluorescence enhancement response. The probe showed high sensitivity (0.8 ppb), and fast response time (<10 s) of Fe(III) in aqueous media. In addition, the probe showed the ability to sense Fe(III) in a HeLa cancer cell line, with very low cytotoxicity. As a new bio-imaging probe for Fe(III), it gave bright fluorescent images in confocal laser scanning microscopy (CLSM).

Original languageEnglish
Article number2500
JournalSensors (Switzerland)
Volume19
Issue number11
DOIs
Publication statusPublished - 2019 Jun 1

Bibliographical note

Funding Information:
SSuupppplleemmeennttaarryy MMataetreirailasl:s:T hTehfeo lfloowlloinwginagre aarvea ialavbalielaobnleli noenaltinhet tpa:t//wwwwww.m.mddppi.ic.coomm/1/x4x2x4/-s812,20S/u1p9/p1l1e/m25e0n0t/asr1y, Figures: summary of known fluorescent probes, UV/Vis absorption and fluorescence spectra, ESIPT pathway, ESIPTNMR analysis, pathway,HR-mass speNMR analysis,ctra. HR-mass spectra. Author Contributions: N.H.K. performed the synthesis, characterization, and sensing study. J.L. and S.P. Author Contributions: N.H.K. performed the synthesis, characterization, and sensing study. J.L. and S.P. performed the quantum chemical calculation. J.J. performed bio-related study. D.K. conceived the project, analyzed the data and wrote the manuscript with J.J. Funding: This research was supported by the Bio & Medical Technology Development Program of the National Funding: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) of Korea funded by the Ministry of Science & ICT (NRF-2018-M3A9H3021707) and of Education (NRF-2018R1A6A1A03025124, NRF-2018R1D1A1B07043383). Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the ministry of Education (NRF-2018R1A6A1A03025124, NRF-2018R1D1A1B07043383).

Publisher Copyright:
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Keywords

  • Bioimaging
  • D-A type fluorophore
  • Fluorescent probe
  • Iron ion sensing
  • Schiff base probe

ASJC Scopus subject areas

  • Analytical Chemistry
  • Information Systems
  • Atomic and Molecular Physics, and Optics
  • Biochemistry
  • Instrumentation
  • Electrical and Electronic Engineering

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