@article{5aadc771e0ea4dcabdf3655382dc1e00,
title = "A short PEG linker alters thein vivopharmacokinetics of trastuzumab to yield high-contrast immuno-PET images",
abstract = "The prolonged blood circulation of the radiolabeled antibody conjugates is problematic when using immuno-PET imaging due to the increased radiation exposure and longer hospitalization required until sufficient contrast develops. In contrast to the prevailing belief that PEGylation prolongs blood retention time, we observed that a PEGylated antibody with a short PEG8linker cleared much faster from the blood while maintaining tumor uptake compared to its non-PEGylated counterpart. Breast tumors were clearly visualized with a very high tumor-to-background ratio as early as 24 h after injection in immuno-positron emission tomography (PET) imaging.",
author = "Woonghee Lee and Bobba, {Kondapa Naidu} and Kim, {Jung Young} and Hyun Park and Abhinav Bhise and Wanook Kim and Kiwoong Lee and Subramani Rajkumar and Bora Nam and Lee, {Kyo Chul} and Lee, {Sang Hyuk} and Sanghwan Ko and Lee, {Hye Jin} and Jung, {Sang Taek} and Jeongsoo Yoo",
note = "Funding Information: aDepartment of Molecular Medicine, Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea. E-mail: yooj@knu.ac.kr bDivision of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea cDepartment of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, 80 Daehakro, Buk-gu, Daegu, 41566, Republic of Korea dBK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea eInstitute of Human Genetics, Korea University College of Medicine, Seoul 02841, Republic of Korea Funding Information: This work was supported by the R&D program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (No. 2019R1A2C2084313, 2020M2D8A3094031 and 2019H1D3A1A01102643). This research was partially supported by Kyungpook National University Development Project Research Fund, 2020. The Korea Basic Science Institute is acknowledged for MALDI-MS measurements. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",
year = "2021",
month = apr,
day = "7",
doi = "10.1039/d0tb02911d",
language = "English",
volume = "9",
pages = "2993--2997",
journal = "Journal of Materials Chemistry B",
issn = "2050-750X",
publisher = "Royal Society of Chemistry",
number = "13",
}