A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers

Jungyoup Jay Han; Junhai Kai; Se Hwan Lee; Aniruddha Puntambekar; Ji Youn Lim; Donggeun Sul; Chong H. Ahn

doi:10.31438/trf.hh2012.47

A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers

Jungyoup Jay Han, Junhai Kai, Se Hwan Lee, Aniruddha Puntambekar, Ji Youn Lim, Donggeun Sul, Chong H. Ahn

Department of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires < ∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.

Original language	English
Title of host publication	2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
Editors	Mehran Mehregany, David J. Monk
Publisher	Transducer Research Foundation
Pages	177-180
Number of pages	4
ISBN (Electronic)	9780964002494
DOIs	https://doi.org/10.31438/trf.hh2012.47
Publication status	Published - 2012
Event	2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States Duration: 2012 Jun 3 → 2012 Jun 7

Publication series

Name	Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Other

Other	2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
Country/Territory	United States
City	Hilton Head
Period	12/6/3 → 12/6/7

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering
Hardware and Architecture

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.31438/trf.hh2012.47

Cite this

Han, J. J., Kai, J., Lee, S. H., Puntambekar, A., Lim, J. Y., Sul, D., & Ahn, C. H. (2012). A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers. In M. Mehregany, & D. J. Monk (Eds.), 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 (pp. 177-180). (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). Transducer Research Foundation. https://doi.org/10.31438/trf.hh2012.47

A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers. / Han, Jungyoup Jay; Kai, Junhai; Lee, Se Hwan et al.
2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. ed. / Mehran Mehregany; David J. Monk. Transducer Research Foundation, 2012. p. 177-180 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Han, JJ, Kai, J, Lee, SH, Puntambekar, A, Lim, JY, Sul, D & Ahn, CH 2012, A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers. in M Mehregany & DJ Monk (eds), 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop, Transducer Research Foundation, pp. 177-180, 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012, Hilton Head, United States, 12/6/3. https://doi.org/10.31438/trf.hh2012.47

Han JJ, Kai J, Lee SH, Puntambekar A, Lim JY, Sul D et al. A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers. In Mehregany M, Monk DJ, editors, 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. Transducer Research Foundation. 2012. p. 177-180. (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). doi: 10.31438/trf.hh2012.47

Han, Jungyoup Jay ; Kai, Junhai ; Lee, Se Hwan et al. / A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers. 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. editor / Mehran Mehregany ; David J. Monk. Transducer Research Foundation, 2012. pp. 177-180 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

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abstract = "A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires < ∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.",

author = "Han, {Jungyoup Jay} and Junhai Kai and Lee, {Se Hwan} and Aniruddha Puntambekar and Lim, {Ji Youn} and Donggeun Sul and Ahn, {Chong H.}",

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AB - A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires < ∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.

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A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers

Abstract

Publication series

Other

ASJC Scopus subject areas

UN SDGs

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