Abstract
A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires < ∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.
| Original language | English |
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| Title of host publication | 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 |
| Editors | Mehran Mehregany, David J. Monk |
| Publisher | Transducer Research Foundation |
| Pages | 177-180 |
| Number of pages | 4 |
| ISBN (Electronic) | 9780964002494 |
| DOIs | |
| Publication status | Published - 2012 |
| Event | 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States Duration: 2012 Jun 3 → 2012 Jun 7 |
Publication series
| Name | Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop |
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Other
| Other | 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 |
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| Country/Territory | United States |
| City | Hilton Head |
| Period | 12/6/3 → 12/6/7 |
Bibliographical note
Publisher Copyright:© 2012 TRF.
ASJC Scopus subject areas
- Control and Systems Engineering
- Electrical and Electronic Engineering
- Hardware and Architecture
