TY - GEN
T1 - A smart biochip with hand-held analyzer for monitoring specific environmental biomarkers
AU - Han, Jungyoup Jay
AU - Kai, Junhai
AU - Lee, Se Hwan
AU - Puntambekar, Aniruddha
AU - Lim, Ji Youn
AU - Sul, Donggeun
AU - Ahn, Chong H.
N1 - Publisher Copyright:
© 2012 TRF.
PY - 2012
Y1 - 2012
N2 - A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires < ∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.
AB - A new smart disposable biochip with a hand-held analyzer for monitoring specific environmental proteomic biomarkers has been designed, developed and fully characterized using polymer microfabrication technology and chemiluminescence immunoassay detection method. High sensitivity, small size, and low cost of the developed system are very suitable for exposure monitoring as a point-of-care (POC) platform. In this paper, Rho GDP inhibitor and triose phosphate isomerase as potential environmental biomarkers of di(2-ethylhexl) phthalate (DEHP) and human disease associate with DEHP were used for the developed biochip with the analyzer, demonstrating a POC platform. The smart biochip based analysis only requires < ∼30 minutes, comparing to 4∼5 hours of a conventional ELISA.
UR - http://www.scopus.com/inward/record.url?scp=84944673580&partnerID=8YFLogxK
U2 - 10.31438/trf.hh2012.47
DO - 10.31438/trf.hh2012.47
M3 - Conference contribution
AN - SCOPUS:84944673580
T3 - Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop
SP - 177
EP - 180
BT - 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
A2 - Mehregany, Mehran
A2 - Monk, David J.
PB - Transducer Research Foundation
T2 - 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
Y2 - 3 June 2012 through 7 June 2012
ER -