A Synbiotic Combination of Lactobacillus gasseri 505 and Cudrania tricuspidata Leaf Extract Prevents Stress-Induced Testicular Dysfunction in Mice

Jae Yeon Joung, Whasun Lim, Yeon Jeong Seo, Jiyeon Ham, Nam Su Oh, Sae Hun Kim

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

This study investigated the effects of a synbiotic combination (Syn) of Lactobacillus gasseri 505 (505) and Cudrania tricuspidata leaf extract (CT) on the hypothalamic-pituitary-gonadal axis in mice under chronic stress. Unpredictable chronic mild stress (UCMS) significantly increased the serum levels of corticosterone, however, treatment with Syn suppressed UCMS-induced increases. Histopathological analysis of the testes showed that these organs experienced some damage during UCMS, but this was repaired following treatment with Syn. Similarly, the transcription levels of gonadotropin-releasing hormone (GnRH), GnRH receptor, and gonadotropins, moreover, testicular development (i.e., Adam5, Adam29, and Spam1) - and steroidogenesis (i.e., Lhr, Egfr, and StAR) -related genes were significantly downregulated by UCMS. These UCMS-induced changes were inhibited by the administration of Syn, which was confirmed by the results of in situ hybridization analysis. These results suggest that the administration of Syn could attenuate the testicular dysfunctions induced by UCMS.

Original languageEnglish
Article number835033
JournalFrontiers in Endocrinology
Volume13
DOIs
Publication statusPublished - 2022 Apr 20

Bibliographical note

Funding Information:
This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (321036-5) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2020R1F1A1055542).

Publisher Copyright:
Copyright © 2022 Joung, Lim, Seo, Ham, Oh and Kim.

Keywords

  • Cudrania tricuspidata leaf extract
  • Lactobacillus gasseri 505
  • chronic stress
  • male reproductive function
  • synbiotics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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