A three-dimensional and sensitive bioassay based on nanostructured quartz combined with viral nanoparticles

Jong Hwan Lee, Jung Suk Kim, Jin Seung Park, Wonbae Lee, Kyung Eun Lee, Sung Sik Han, Kyu Back Lee, Jeewon Lee

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)

    Abstract

    An effective mask-free method for fabricating high-aspect-ratio pillarlike nanostructures over a large area of a quartz surface via a simple O2 and CF4 two-step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease markers.

    Original languageEnglish
    Pages (from-to)2004-2009
    Number of pages6
    JournalAdvanced Functional Materials
    Volume20
    Issue number12
    DOIs
    Publication statusPublished - 2010 Jun 23

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • General Chemistry
    • Condensed Matter Physics
    • General Materials Science
    • Electrochemistry
    • Biomaterials

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