Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain

Kyungsoon Chung; Hee Jin Kim; Heung Sik Na; Mae Ja Park; Jin Mo Chung

doi:10.1016/0304-3940(93)90566-4

Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain

Kyungsoon Chung
, Hee Jin Kim
, Heung Sik Na
, Mae Ja Park
, Jin Mo Chung^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

158 Citations (Scopus)

Abstract

Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after a tight ligation of the L₅ spinal nerve, putative sympathetic postganglionic fibers were examined in the injured spinal nerve and the dorsal root ganglion (DRG), using immunohistochemical staining with antibody against tyrosine hydroxylase (TH). In the neuropathic rats, there was an increase in the number of TH-immunolabeled fibers in the spinal nerve, and some DRG cells were surrounded by the labeled fibers. These abnormalities of sympathetic postganglionic innervation of the injured spinal nerve or the DRG may be a part of the mechanisms underlying the development of SMP.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	Neuroscience Letters
Volume	162
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(93)90566-4
Publication status	Published - 1993 Nov 12

Bibliographical note

Funding Information:
This work was supported by NIH Grants NS 21266 and NS 11255, the John Sealy Memorial Endowment Fund and a grant from Bristol-Myers Squibb Co. H.S.N. was supported in part by the Kil Chung Hee Fellowship Fund. We wish to thank M.L. Watson for editorial help.

Keywords

Causalgia
Dorsal root ganglion
Hyperalgesia
Mechanical allodynia
Peripheral nerve injury
Sympathetically maintained pain
Tyrosine hydroxylase

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(93)90566-4

Cite this

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title = "Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain",

abstract = "Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after a tight ligation of the L5 spinal nerve, putative sympathetic postganglionic fibers were examined in the injured spinal nerve and the dorsal root ganglion (DRG), using immunohistochemical staining with antibody against tyrosine hydroxylase (TH). In the neuropathic rats, there was an increase in the number of TH-immunolabeled fibers in the spinal nerve, and some DRG cells were surrounded by the labeled fibers. These abnormalities of sympathetic postganglionic innervation of the injured spinal nerve or the DRG may be a part of the mechanisms underlying the development of SMP.",

keywords = "Causalgia, Dorsal root ganglion, Hyperalgesia, Mechanical allodynia, Peripheral nerve injury, Sympathetically maintained pain, Tyrosine hydroxylase",

author = "Kyungsoon Chung and Kim, \{Hee Jin\} and Na, \{Heung Sik\} and Park, \{Mae Ja\} and Chung, \{Jin Mo\}",

note = "Funding Information: This work was supported by NIH Grants NS 21266 and NS 11255, the John Sealy Memorial Endowment Fund and a grant from Bristol-Myers Squibb Co. H.S.N. was supported in part by the Kil Chung Hee Fellowship Fund. We wish to thank M.L. Watson for editorial help.",

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AU - Chung, Kyungsoon

AU - Kim, Hee Jin

AU - Na, Heung Sik

AU - Park, Mae Ja

AU - Chung, Jin Mo

N1 - Funding Information: This work was supported by NIH Grants NS 21266 and NS 11255, the John Sealy Memorial Endowment Fund and a grant from Bristol-Myers Squibb Co. H.S.N. was supported in part by the Kil Chung Hee Fellowship Fund. We wish to thank M.L. Watson for editorial help.

PY - 1993/11/12

Y1 - 1993/11/12

N2 - Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after a tight ligation of the L5 spinal nerve, putative sympathetic postganglionic fibers were examined in the injured spinal nerve and the dorsal root ganglion (DRG), using immunohistochemical staining with antibody against tyrosine hydroxylase (TH). In the neuropathic rats, there was an increase in the number of TH-immunolabeled fibers in the spinal nerve, and some DRG cells were surrounded by the labeled fibers. These abnormalities of sympathetic postganglionic innervation of the injured spinal nerve or the DRG may be a part of the mechanisms underlying the development of SMP.

AB - Using the rat model that we have developed, a potential underlying mechanism for sympathetically maintained neuropathic pain (SMP) was explored. In rats showing neuropathic pain behaviors after a tight ligation of the L5 spinal nerve, putative sympathetic postganglionic fibers were examined in the injured spinal nerve and the dorsal root ganglion (DRG), using immunohistochemical staining with antibody against tyrosine hydroxylase (TH). In the neuropathic rats, there was an increase in the number of TH-immunolabeled fibers in the spinal nerve, and some DRG cells were surrounded by the labeled fibers. These abnormalities of sympathetic postganglionic innervation of the injured spinal nerve or the DRG may be a part of the mechanisms underlying the development of SMP.

KW - Causalgia

KW - Dorsal root ganglion

KW - Hyperalgesia

KW - Mechanical allodynia

KW - Peripheral nerve injury

KW - Sympathetically maintained pain

KW - Tyrosine hydroxylase

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DO - 10.1016/0304-3940(93)90566-4

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AN - SCOPUS:0027424983

SN - 0304-3940

VL - 162

SP - 85

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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