Accuracy of lung nodule volumetry in low-dose CT with iterative reconstruction: An anthropomorphic thoracic phantom study

K. W. Doo, E. Y. Kang, H. S. Yong, O. H. Woo, K. Y. Lee, Y. W. Oh

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43 Citations (Scopus)


Objective: The purpose of this studywas to assess accuracy of lung nodule volumetry in low-dose CT with application of iterative reconstruction (IR) according to nodule size, nodule density and CT tube currents, using artificial lung nodules within an anthropomorphic thoracic phantom.

Methods: Eight artificial nodules (four diameters: 5, 8, 10 and 12mm; two CT densities: -630HU that represents ground-glass nodule and +100HU that represents solid nodule) were randomly placed inside a thoracic phantom. Scans were performed with tube current-time product to 10, 20, 30 and 50mAs. Images were reconstructed with IR and filtered back projection (FBP). We compared volume estimates to a reference standard and calculated the absolute percentage error (APE).

Results: The APE of all nodules was significantly lower when IR was used than with FBP (7.5± 4.7% compared with 9.0±6.9%; p<0.001). The effect of IR was more pronounced for smaller nodules (p<0.001). IR showed a significantly lower APE than FBP in ground-glass nodules (p<0.0001), and the difference was more pronounced at the lowest tube current (11.8±5.9% compared with 21.3± 6.1%; p<0.0001). The effect of IR was most pronounced for ground-glass nodules in the lowest CT tube current.

Conclusion: Lung nodule volumetry in low-dose CT by application of IR showed reliable accuracy in a phantom study. Lung nodule volumetry can be reliably applicable to all lung nodules including small, ground-glass nodules even in ultra-low-dose CT with application of IR.

Advances in knowledge: IR significantly improved the accuracy of lung nodule volumetry compared with FBP particularly for ground-glass (-630HU) nodules. Volumetry in low-dose CT can be utilized in patient with lung nodule work-up, and IR has benefit for small, groundglass lung nodules in low-dose CT.

Original languageEnglish
Article number20130644
JournalBritish Journal of Radiology
Issue number1041
Publication statusPublished - 2014 Sept 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 The Authors.

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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