TY - GEN
T1 - Acoustic device for selective platelet extraction from whole blood
AU - Nam, Jeonghun
AU - Lim, Hyunjung
AU - Kim, Dookon
AU - Shin, Sehyun
PY - 2011
Y1 - 2011
N2 - Platelet separation from blood is fundamental technique for biochemical analyses. In this article, we proposed a method to collect platelets from whole blood utilizing standing surface acoustic waves (SSAWs) in a microfluidic device. A polydimethylsiloxane (PDMS) microfluidic device was integrated with interdigitated transducers (IDTs) on a piezoelectric substrate. Whole blood sample was hydrodynamically focused by sheath flow from side inlets. Pressure nodes were designed to locate at side walls, thereby collecting platelets with minimum shear effect. Finally, the RBC clearance ratio from whole blood was found to be 99% and the purity of platelets was close to 98%.
AB - Platelet separation from blood is fundamental technique for biochemical analyses. In this article, we proposed a method to collect platelets from whole blood utilizing standing surface acoustic waves (SSAWs) in a microfluidic device. A polydimethylsiloxane (PDMS) microfluidic device was integrated with interdigitated transducers (IDTs) on a piezoelectric substrate. Whole blood sample was hydrodynamically focused by sheath flow from side inlets. Pressure nodes were designed to locate at side walls, thereby collecting platelets with minimum shear effect. Finally, the RBC clearance ratio from whole blood was found to be 99% and the purity of platelets was close to 98%.
KW - Microfluidics
KW - Platelets
KW - Separation
KW - Standing surface acoustic wave
UR - http://www.scopus.com/inward/record.url?scp=84883763556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883763556&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84883763556
SN - 9781618395955
T3 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
SP - 1326
EP - 1328
BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Y2 - 2 October 2011 through 6 October 2011
ER -