Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids

Keyphrases

• Anticancer Therapy 25%
• Cell-cell Interaction 12%
• Chemoresistance 100%
• Cisplatin 12%
• Collagen 1A1 37%
• Collagen I 12%
• Collagen Matrix 12%
• Fibroblasts 12%
• Hepatic Stellate Cell Activation 100%
• Hepatic Stellate Cells 50%
• Hepatocellular Carcinoma 75%
• Hepatocellular Carcinoma Cells 100%
• Liver Cancer Treatment 12%
• Losartan 12%
• Matrix metalloproteinase-9 (MMP-9) 25%
• Multicellular Tumor Spheroids 100%
• Sorafenib 12%
• Stromal Cells 12%
• Strong Resistance 12%
• Therapeutic Efficacy 25%
• Therapeutic Strategies 12%
• Tumor Microenvironment 12%
• Unmet Medical Need 12%
• Vascular Endothelial Cells 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Cisplatin 12%
• Combination Therapy 25%
• Drug Resistance 100%
• Liver Cancer 12%
• Liver Cell Carcinoma 100%
• Losartan 12%
• Matrix Metalloproteinase 25%
• Neoplasm 100%
• Sorafenib 12%
• Tumor Microenvironment 12%

Biochemistry, Genetics and Molecular Biology

• Anticancer 20%
• Cell-Cell Interaction 10%
• Cisplatin 10%
• Coculture 10%
• Drug Resistance 100%
• Fibroblast 10%
• Hepatic Stellate Cell 100%
• Matrix Metalloproteinase 20%
• Sorafenib 10%
• Stromal Cell 10%
• Tumor Spheroid 100%