Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene

Dipanjan Chanda; Yong Hoon Kim; Don Kyu Kim; Min Woo Lee; Su Yeon Lee; Tae Sik Park; Seung Hoi Koo; Chul Ho Lee; Hueng Sik Choi

doi:10.1074/jbc.M112.377978

Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene

Dipanjan Chanda, Yong Hoon Kim, Don Kyu Kim, Min Woo Lee, Su Yeon Lee, Tae Sik Park, Seung Hoi Koo, Chul Ho Lee, Hueng Sik Choi

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Background: The role of Cb1r signaling-mediated activation of Crebh in regulating lipid metabolism and insulin signaling is currently unknown. Results: Cb1r signaling regulates Lipin1 gene transcription via Crebh and inhibits insulin receptor signaling. Conclusion: Crebh-mediated activation of Lipin1 by Cb1r deregulates insulin receptor signaling. Significance: Relieving higher hepatic DAG levels by targeting its upstream regulators might be beneficial to restore insulin signaling.

Original language	English
Pages (from-to)	38041-38049
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	287
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M112.377978
Publication status	Published - 2012 Nov 2
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Chanda, D., Kim, Y. H., Kim, D. K., Lee, M. W., Lee, S. Y., Park, T. S., Koo, S. H., Lee, C. H., & Choi, H. S. (2012). Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. Journal of Biological Chemistry, 287(45), 38041-38049. https://doi.org/10.1074/jbc.M112.377978

Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene. / Chanda, Dipanjan; Kim, Yong Hoon; Kim, Don Kyu et al.
In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 38041-38049.

Research output: Contribution to journal › Article › peer-review

Chanda, D, Kim, YH, Kim, DK, Lee, MW, Lee, SY, Park, TS, Koo, SH, Lee, CH & Choi, HS 2012, 'Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene', Journal of Biological Chemistry, vol. 287, no. 45, pp. 38041-38049. https://doi.org/10.1074/jbc.M112.377978

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abstract = "Background: The role of Cb1r signaling-mediated activation of Crebh in regulating lipid metabolism and insulin signaling is currently unknown. Results: Cb1r signaling regulates Lipin1 gene transcription via Crebh and inhibits insulin receptor signaling. Conclusion: Crebh-mediated activation of Lipin1 by Cb1r deregulates insulin receptor signaling. Significance: Relieving higher hepatic DAG levels by targeting its upstream regulators might be beneficial to restore insulin signaling.",

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AU - Kim, Don Kyu

AU - Lee, Min Woo

AU - Lee, Su Yeon

AU - Park, Tae Sik

AU - Koo, Seung Hoi

AU - Lee, Chul Ho

AU - Choi, Hueng Sik

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Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene

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