Background: The role of Cb1r signaling-mediated activation of Crebh in regulating lipid metabolism and insulin signaling is currently unknown. Results: Cb1r signaling regulates Lipin1 gene transcription via Crebh and inhibits insulin receptor signaling. Conclusion: Crebh-mediated activation of Lipin1 by Cb1r deregulates insulin receptor signaling. Significance: Relieving higher hepatic DAG levels by targeting its upstream regulators might be beneficial to restore insulin signaling.
|Number of pages||9|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 2012 Nov 2|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology