Abstract
Peripheral group III metabotropic glutamate receptors (mGluRs) function to modulate pain signaling in inflammatory states. Here, we established in vivo experimental settings, including dynamic weight bearing test and in vivo single nerve recording, to elucidate how the group III mGluRs contribute to inhibiting pain transmission at the peripheral sensory nerve terminal in inflammatory states (1 and 3 days) elicited by Complete Freund's Adjuvant (CFA). As a result, CFA-induced nociceptive behaviors were significantly alleviated after administration of 100 and 200 μM L-AP4 (l-2-amino-4-phosphonobutylate; group III mGluR agonist). In addition, neuronal discharges evoked by 6- and 26-g von Frey filaments at the nerve significantly decreased after administration of 200 μM L-AP4. However, this event was not observed in non-inflammatory state. These results suggest that the group III mGluRs negatively regulate nociceptive behavior and pain transmission by lessening neuronal firing rates at the peripheral nerve in inflammation.
Original language | English |
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Pages (from-to) | 111-115 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 694 |
DOIs | |
Publication status | Published - 2019 Feb 16 |
Bibliographical note
Funding Information:This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2016R1D1A1B03933951), and partially supported by Korea University grant (K1813201), Korea University Research Fellowship Grant Program, and the Chung Yang, Cha Young Sun & Jang Hi Joo Memorial Fund (20140101).
Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2016R1D1A1B03933951 ), and partially supported by Korea University grant ( K1813201 ), Korea University Research Fellowship Grant Program , and the Chung Yang, Cha Young Sun & Jang Hi Joo Memorial Fund ( 20140101 ).
Publisher Copyright:
© 2018
Keywords
- CFA
- Dynamic weight bearing
- Group III mGluR
- In vivo single nerve recording
- Knee joint
- Pain transmission
ASJC Scopus subject areas
- General Neuroscience