Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

Jin Wook Lee, Jae Hong Kim

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.

    Original languageEnglish
    Pages (from-to)30054-30063
    Number of pages10
    JournalJournal of Biological Chemistry
    Volume288
    Issue number42
    DOIs
    Publication statusPublished - 2013 Oct 18

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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