Abstract
Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.
| Original language | English |
|---|---|
| Pages (from-to) | 30054-30063 |
| Number of pages | 10 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 42 |
| DOIs | |
| Publication status | Published - 2013 Oct 18 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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