Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

Jin Wook Lee; Jae Hong Kim

doi:10.1074/jbc.M113.481283

Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

Jin Wook Lee
, Jae Hong Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.

Original language	English
Pages (from-to)	30054-30063
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.481283
Publication status	Published - 2013 Oct 18

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1074/jbc.M113.481283

Cite this

@article{0a48ca5b0de44b5d974d951b9caff3b4,

title = "Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells",

abstract = "Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.",

author = "Lee, \{Jin Wook\} and Kim, \{Jae Hong\}",

year = "2013",

month = oct,

day = "18",

doi = "10.1074/jbc.M113.481283",

language = "English",

volume = "288",

pages = "30054--30063",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "42",

}

TY - JOUR

T1 - Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

AU - Lee, Jin Wook

AU - Kim, Jae Hong

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.

AB - Background: Despite the critical role of anoikis resistance in prostate cancer progression, the molecular mechanism causing anoikis resistance remains unclear. Results: BLT2 protects prostate cancer cells against anoikis via a NOX-ROS-NF-B-linked pathway. Conclusion: Activation of the BLT2-linked pathway following cell detachment confers anoikis resistance. Significance: Our findings suggest BLT2 as a key regulator of anoikis resistance in prostate cancer cells.

UR - https://www.scopus.com/pages/publications/84886875955

U2 - 10.1074/jbc.M113.481283

DO - 10.1074/jbc.M113.481283

M3 - Article

C2 - 23986446

AN - SCOPUS:84886875955

SN - 0021-9258

VL - 288

SP - 30054

EP - 30063

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 42

ER -

Activation of the leukotriene B4 receptor 2-reactive oxygen species (BLT2-ROS) cascade following detachment confers anoikis resistance in prostate cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this