TY - JOUR
T1 - Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes
AU - Mao, Zhiqiang
AU - Xiong, Jianhua
AU - Wang, Pengzhan
AU - An, Jusung
AU - Zhang, Fan
AU - Liu, Zhihong
AU - Seung Kim, Jong
N1 - Funding Information:
This work was financially supported by the National Natural Science Foundation of China (Nos. 22174034 , 21804033 , 21625503 , and 21904031 ), the Foundation for Creative Research Groups of Hubei Province of China (No. 2020CFA035), the Natural Science Foundation of Hubei Province ( 2021CFB305 ), and funded by the National Research Foundation of Korea (CRI project No. 2018R1A3B1052702, NRF-2019M3E5D1A01068998, J. S. Kim) and the Korea University Graduate School Junior Fellow Research Grant (J. An).
Publisher Copyright:
© 2021
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Peroxynitrite (ONOO−), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO− over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO− related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO− in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes’ applications in chemistry, biology, and pharmacology.
AB - Peroxynitrite (ONOO−), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO− over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO− related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO− in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes’ applications in chemistry, biology, and pharmacology.
KW - Activity-based sensing
KW - Fluorescent probe
KW - Inflammation
KW - Peroxynitrite
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=85121244917&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2021.214356
DO - 10.1016/j.ccr.2021.214356
M3 - Review article
AN - SCOPUS:85121244917
SN - 0010-8545
VL - 454
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 214356
ER -