Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Zhiqiang Mao; Jianhua Xiong; Pengzhan Wang; Jusung An; Fan Zhang; Zhihong Liu; Jong Seung Kim

doi:10.1016/j.ccr.2021.214356

Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Zhiqiang Mao, Jianhua Xiong, Pengzhan Wang, Jusung An, Fan Zhang, Zhihong Liu, Jong Seung Kim

Research output: Contribution to journal › Review article › peer-review

93 Citations (Scopus)

Abstract

Peroxynitrite (ONOO⁻), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO⁻ over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO⁻ related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO⁻ in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes’ applications in chemistry, biology, and pharmacology.

Original language	English
Article number	214356
Journal	Coordination Chemistry Reviews
Volume	454
DOIs	https://doi.org/10.1016/j.ccr.2021.214356
Publication status	Published - 2022 Mar 1

Bibliographical note

Funding Information:
This work was financially supported by the National Natural Science Foundation of China (Nos. 22174034 , 21804033 , 21625503 , and 21904031 ), the Foundation for Creative Research Groups of Hubei Province of China (No. 2020CFA035), the Natural Science Foundation of Hubei Province ( 2021CFB305 ), and funded by the National Research Foundation of Korea (CRI project No. 2018R1A3B1052702, NRF-2019M3E5D1A01068998, J. S. Kim) and the Korea University Graduate School Junior Fellow Research Grant (J. An).

Publisher Copyright:
© 2021

Keywords

Activity-based sensing
Fluorescent probe
Inflammation
Peroxynitrite
Tumor

ASJC Scopus subject areas

Materials Chemistry
General Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry

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10.1016/j.ccr.2021.214356

Cite this

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title = "Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes",

abstract = "Peroxynitrite (ONOO−), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO− over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO− related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO− in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes{\textquoteright} applications in chemistry, biology, and pharmacology.",

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author = "Zhiqiang Mao and Jianhua Xiong and Pengzhan Wang and Jusung An and Fan Zhang and Zhihong Liu and {Seung Kim}, Jong",

note = "Funding Information: This work was financially supported by the National Natural Science Foundation of China (Nos. 22174034 , 21804033 , 21625503 , and 21904031 ), the Foundation for Creative Research Groups of Hubei Province of China (No. 2020CFA035), the Natural Science Foundation of Hubei Province ( 2021CFB305 ), and funded by the National Research Foundation of Korea (CRI project No. 2018R1A3B1052702, NRF-2019M3E5D1A01068998, J. S. Kim) and the Korea University Graduate School Junior Fellow Research Grant (J. An). Publisher Copyright: {\textcopyright} 2021",

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AU - Zhang, Fan

AU - Liu, Zhihong

AU - Seung Kim, Jong

N1 - Funding Information: This work was financially supported by the National Natural Science Foundation of China (Nos. 22174034 , 21804033 , 21625503 , and 21904031 ), the Foundation for Creative Research Groups of Hubei Province of China (No. 2020CFA035), the Natural Science Foundation of Hubei Province ( 2021CFB305 ), and funded by the National Research Foundation of Korea (CRI project No. 2018R1A3B1052702, NRF-2019M3E5D1A01068998, J. S. Kim) and the Korea University Graduate School Junior Fellow Research Grant (J. An). Publisher Copyright: © 2021

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N2 - Peroxynitrite (ONOO−), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO− over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO− related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO− in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes’ applications in chemistry, biology, and pharmacology.

AB - Peroxynitrite (ONOO−), one of the reactive oxygen and nitrogen species (RONS), is famous for its potent oxidation and nitration capabilities and plays crucial roles in various pathological conditions. Given the similar chemical properties of various RONS (e.g. short half-life time, ultralow content, and mutual interconversion), specific detecting of ONOO− over other RONS remains a challenging mission in the complex physiological environment, primarily ONOO− related pathological processes. To decipher the intricate associations, molecular imaging assisted by activity-based sensing (ABS) fluorescent probes has become the “state-of-art” method due to its superiorities, including susceptible and selective detection results, non-invasive and real-time visualization. This review focuses on the research of ABS fluorescent probes that revealed the vital roles of ONOO− in various diseases, such as inflammations, tumors, liver injuries, and brain diseases. Finally, we discuss the bottlenecks and future developing trends for ABS probes which will boost ABS probes’ applications in chemistry, biology, and pharmacology.

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Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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