Activity-dependent conduction velocity changes of Aδ fibers in a rat model of neuropathy

Chung Kil Won; Seung Jae Oh; Sung Cherl Jung; Young Ryong Choi; Yang In Kim; Joong Woo Leem; Hyung Cheul Shin

doi:10.1097/00001756-199710200-00004

Activity-dependent conduction velocity changes of Aδ fibers in a rat model of neuropathy

Chung Kil Won, Seung Jae Oh, Sung Cherl Jung, Young Ryong Choi, Yang In Kim, Joong Woo Leem, Hyung Cheul Shin

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

ACTIVITY-DEPENDENT changes of conduction velocity (CV) and conduction block in single Aδ fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of Aδ DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.

Original language	English
Pages (from-to)	3201-3205
Number of pages	5
Journal	Neuroreport
Volume	8
Issue number	15
DOIs	https://doi.org/10.1097/00001756-199710200-00004
Publication status	Published - 1997
Externally published	Yes

Keywords

Activity dependence
Axon
Conduction block
Conduction velocity
Dorsal root fiber
Hyperalgesia
Neuropathy
Primary afferent nerve

ASJC Scopus subject areas

General Neuroscience

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10.1097/00001756-199710200-00004

Cite this

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title = "Activity-dependent conduction velocity changes of Aδ fibers in a rat model of neuropathy",

abstract = "ACTIVITY-DEPENDENT changes of conduction velocity (CV) and conduction block in single Aδ fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of Aδ DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.",

keywords = "Activity dependence, Axon, Conduction block, Conduction velocity, Dorsal root fiber, Hyperalgesia, Neuropathy, Primary afferent nerve",

author = "Won, {Chung Kil} and Oh, {Seung Jae} and Jung, {Sung Cherl} and Choi, {Young Ryong} and Kim, {Yang In} and Leem, {Joong Woo} and Shin, {Hyung Cheul}",

year = "1997",

doi = "10.1097/00001756-199710200-00004",

language = "English",

volume = "8",

pages = "3201--3205",

journal = "Neuroreport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

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T1 - Activity-dependent conduction velocity changes of Aδ fibers in a rat model of neuropathy

AU - Won, Chung Kil

AU - Oh, Seung Jae

AU - Jung, Sung Cherl

AU - Choi, Young Ryong

AU - Kim, Yang In

AU - Leem, Joong Woo

AU - Shin, Hyung Cheul

PY - 1997

Y1 - 1997

N2 - ACTIVITY-DEPENDENT changes of conduction velocity (CV) and conduction block in single Aδ fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of Aδ DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.

AB - ACTIVITY-DEPENDENT changes of conduction velocity (CV) and conduction block in single Aδ fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of Aδ DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.

KW - Activity dependence

KW - Axon

KW - Conduction block

KW - Conduction velocity

KW - Dorsal root fiber

KW - Hyperalgesia

KW - Neuropathy

KW - Primary afferent nerve

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U2 - 10.1097/00001756-199710200-00004

DO - 10.1097/00001756-199710200-00004

M3 - Article

C2 - 9351643

AN - SCOPUS:0030730505

SN - 0959-4965

VL - 8

SP - 3201

EP - 3205

JO - Neuroreport

JF - Neuroreport

IS - 15

ER -

Activity-dependent conduction velocity changes of Aδ fibers in a rat model of neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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