Activity-dependent conduction velocity changes of Aδ fibers in a rat model of neuropathy

Chung Kil Won, Seung Jae Oh, Sung Cherl Jung, Young Ryong Choi, Yang In Kim, Joong Woo Leem, Hyung Cheul Shin

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


ACTIVITY-DEPENDENT changes of conduction velocity (CV) and conduction block in single Aδ fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of Aδ DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.

Original languageEnglish
Pages (from-to)3201-3205
Number of pages5
Issue number15
Publication statusPublished - 1997
Externally publishedYes


  • Activity dependence
  • Axon
  • Conduction block
  • Conduction velocity
  • Dorsal root fiber
  • Hyperalgesia
  • Neuropathy
  • Primary afferent nerve

ASJC Scopus subject areas

  • Neuroscience(all)


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