Actual compliance to adjuvant chemotherapy in gastric cancer

Dong Wook Kim, Oh Kyoung Kwon, Moon Won Yoo, Seung Wan Ryu, Sung Jin Oh, Hoon Hur, Sun Hwi Hwang, Junhyun Lee, Sung Ho Jin, Sang Eok Lee, Jong Han Kim, Jin Jo Kim, In Ho Jeong, Ye Seob Jee

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    Purpose: This study aims to investigate the actual compliance with chemotherapy and analyze several factors affecting the compliance in patients with gastric cancer. Methods: From February 2012 to December 2014, we collected data of patients with gastric cancer who received adjuvant chemotherapy (TS-1 monotherapy or XELOX: capecitabine/oxaliplatin) in Korea. Results: We collected data of 1,089 patients from 31 institutions. The completion rate and dose reduction rate by age (≥60 years vs. <60 years) were 57.5% vs. 76.8% (P < 0.001) and 17.9% vs. 21.3% (P = 0.354); by body mass index (BMI) (≥23 kg/m 2 vs. <23 kg/m 2 ) were 70.2% vs. 63.2% (P = 0.019) and 19.2% vs. 19.9% (P = 0.987), respectively. The compliance by American Society of Anesthesiologists physical status (ASA PS) classification was as follows: completion rate was 74.4%, 62.8%, and 60% (P = 0.001) and the dose reduction rate was 18.4%, 20.7%, and 17.8% (P = 0.946) in ASA PS classification I, II, and III, respectively. The completion rate of TS-1 and XELOX was 65.9% vs. 70.3% (P = 0.206) and the dose reduction rate was 15.7% vs. 33.6% (P < 0.001). Furthermore, the completion rate of chemotherapy by surgical oncologists and medical oncologists was 69.5% vs. 63.2% (P = 0.028) and the dose reduction rate was 17.4% vs. 22.3% (P = 0.035), respectively. Conclusion: The compliance was lower in patients who were older than 60 years, had BMI <23 kg/m 2 , and had higher ASA PS classification. Furthermore, the patients showed higher compliance when they received chemotherapy from surgical oncologists rather than from medical oncologists.

    Original languageEnglish
    Pages (from-to)185-190
    Number of pages6
    JournalAnnals of Surgical Treatment and Research
    Issue number4
    Publication statusPublished - 2019 Apr

    Bibliographical note

    Publisher Copyright:
    Copyright 2019, the Korean Surgical Society


    • Adjuvant chemotherapy
    • Advanced gastric cancer
    • Compliance

    ASJC Scopus subject areas

    • Surgery


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