Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi Hyeon Jang; Min Chul Shin; Taeck Hyun Lee; Baek Vin Lim; Mal Soon Shin; Byung Il Min; Hong Kim; Sonhae Cho; Ee Hwa Kim; Chang Ju Kim

doi:10.1016/S0304-3940(03)00512-3

Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi Hyeon Jang
, Min Chul Shin
, Taeck Hyun Lee
, Baek Vin Lim
, Mal Soon Shin
, Byung Il Min
, Hong Kim
, Sonhae Cho
, Ee Hwa Kim
, Chang Ju Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

Original language	English
Pages (from-to)	5-8
Number of pages	4
Journal	Neuroscience Letters
Volume	347
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(03)00512-3
Publication status	Published - 2003 Aug 14
Externally published	Yes

Keywords

Acupuncture
c-Fos
Caspase-3
Ischemic gerbils
Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
Zusanli acupoint

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(03)00512-3

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@article{17b6138f3e0947849c773e26d0aacb81,

title = "Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils",

abstract = "Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.",

keywords = "Acupuncture, c-Fos, Caspase-3, Ischemic gerbils, Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, Zusanli acupoint",

author = "Jang, \{Mi Hyeon\} and Shin, \{Min Chul\} and Lee, \{Taeck Hyun\} and Lim, \{Baek Vin\} and Shin, \{Mal Soon\} and Min, \{Byung Il\} and Hong Kim and Sonhae Cho and Kim, \{Ee Hwa\} and Kim, \{Chang Ju\}",

year = "2003",

month = aug,

day = "14",

doi = "10.1016/S0304-3940(03)00512-3",

language = "English",

volume = "347",

pages = "5--8",

journal = "Neuroscience Letters",

issn = "0304-3940",

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number = "1",

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TY - JOUR

T1 - Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Taeck Hyun

AU - Lim, Baek Vin

AU - Shin, Mal Soon

AU - Min, Byung Il

AU - Kim, Hong

AU - Cho, Sonhae

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

PY - 2003/8/14

Y1 - 2003/8/14

N2 - Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

AB - Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

KW - Acupuncture

KW - c-Fos

KW - Caspase-3

KW - Ischemic gerbils

KW - Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining

KW - Zusanli acupoint

UR - https://www.scopus.com/pages/publications/0038642510

U2 - 10.1016/S0304-3940(03)00512-3

DO - 10.1016/S0304-3940(03)00512-3

M3 - Article

C2 - 12865128

AN - SCOPUS:0038642510

SN - 0304-3940

VL - 347

SP - 5

EP - 8

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Abstract

Keywords

ASJC Scopus subject areas

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