TY - JOUR
T1 - Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.
AU - Whitehead, Garry
AU - Jo, Jihoon
AU - Hogg, Ellen L.
AU - Piers, Thomas
AU - Kim, Dong Hyun
AU - Seaton, Gillian
AU - Seok, Heon
AU - Bru-Mercier, Gilles
AU - Son, Gi Hoon
AU - Regan, Philip
AU - Hildebrandt, Lars
AU - Waite, Eleanor
AU - Kim, Byeong Chae
AU - Kerrigan, Talitha L.
AU - Kim, Kyungjin
AU - Whitcomb, Daniel J.
AU - Collingridge, Graham L.
AU - Lightman, Stafford L.
AU - Cho, Kwangwook
PY - 2013/12
Y1 - 2013/12
N2 - The neuroendocrine response to episodes of acute stress is crucial for survival whereas the prolonged response to chronic stress can be detrimental. Learning and memory are particularly susceptible to stress with cognitive deficits being well characterized consequences of chronic stress. Although there is good evidence that acute stress can enhance cognitive performance, the mechanism(s) for this are unclear. We find that hippocampal slices, either prepared from rats following 30 min restraint stress or directly exposed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term potentiation. We demonstrate that the mechanism involves an NMDA receptor and PKA-dependent insertion of Ca2+ -permeable AMPA receptors into synapses. These then trigger the additional NMDA receptor-independent form of LTP during high frequency stimulation.
AB - The neuroendocrine response to episodes of acute stress is crucial for survival whereas the prolonged response to chronic stress can be detrimental. Learning and memory are particularly susceptible to stress with cognitive deficits being well characterized consequences of chronic stress. Although there is good evidence that acute stress can enhance cognitive performance, the mechanism(s) for this are unclear. We find that hippocampal slices, either prepared from rats following 30 min restraint stress or directly exposed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term potentiation. We demonstrate that the mechanism involves an NMDA receptor and PKA-dependent insertion of Ca2+ -permeable AMPA receptors into synapses. These then trigger the additional NMDA receptor-independent form of LTP during high frequency stimulation.
UR - http://www.scopus.com/inward/record.url?scp=84893431928&partnerID=8YFLogxK
U2 - 10.1093/brain/awt293
DO - 10.1093/brain/awt293
M3 - Article
C2 - 24271563
AN - SCOPUS:84893431928
SN - 0006-8950
VL - 136
SP - 3753
EP - 3765
JO - Brain : a journal of neurology
JF - Brain : a journal of neurology
IS - Pt 12
ER -