Acute/subacute toxicity of nano calcium

Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticlepeer-review


The objective of this study was to obtain data on the safety-in-use of nano calcium as a dietary supplement by assessing its acute and subacute oral toxicities in female and male Sprague-Dawley rats. A single oral dose of 5,000 mg/kg of nano calcium did not result in mortality or significant changes in the general behavior and gross appearance of the internal organs of rats. For subacute toxicity study, nano calcium was administered orally at a dose of 1,000 mg/kg daily for 14 days. There were no significant differences in organ weights between control and treated groups of both sexes. Hematological analysis and blood chemistry revealed no toxic effects of nano calcium. Pathologically, neither gross abnormalities nor histopathological changes were observed. These results show that nano calcium possesses very low toxicity as indicated in a rat model.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of the Korean Society of Food Science and Nutrition
Issue number1
Publication statusPublished - 2015 Jan 1


  • Acute toxicity
  • Egg shell calcium
  • Nano calcium
  • Subacute toxicity

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Food Science


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