Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

Hyun Kang Jee; Young Lee Yoon; Yeon Yu Byung; Beom Seok Yang; Kyung Hwan Cho; Kyoung Yoon Do; Kyun Roh Yong

doi:10.1007/bf02978210

Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

Hyun Kang Jee, Young Lee Yoon, Yeon Yu Byung, Beom Seok Yang, Kyung Hwan Cho, Kyoung Yoon Do, Kyun Roh Yong

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

Original language	English
Pages (from-to)	1263-1269
Number of pages	7
Journal	Archives of pharmacal research
Volume	28
Issue number	11
DOIs	https://doi.org/10.1007/bf02978210
Publication status	Published - 2005 Nov
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by Konyang University Myung Gok Research Fund of 2004 to Jee Hyun Kang.

Keywords

Adiponectin
Apoptosis
Breast cancer
Growth arrest
MDA-MB-231

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/bf02978210

Cite this

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title = "Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell",

abstract = "Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.",

keywords = "Adiponectin, Apoptosis, Breast cancer, Growth arrest, MDA-MB-231",

author = "Jee, {Hyun Kang} and Yoon, {Young Lee} and Byung, {Yeon Yu} and Yang, {Beom Seok} and Cho, {Kyung Hwan} and Do, {Kyoung Yoon} and Yong, {Kyun Roh}",

note = "Funding Information: This work was supported by Konyang University Myung Gok Research Fund of 2004 to Jee Hyun Kang.",

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doi = "10.1007/bf02978210",

language = "English",

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AU - Jee, Hyun Kang

AU - Yoon, Young Lee

AU - Byung, Yeon Yu

AU - Yang, Beom Seok

AU - Cho, Kyung Hwan

AU - Do, Kyoung Yoon

AU - Yong, Kyun Roh

N1 - Funding Information: This work was supported by Konyang University Myung Gok Research Fund of 2004 to Jee Hyun Kang.

PY - 2005/11

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N2 - Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

AB - Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

KW - Adiponectin

KW - Apoptosis

KW - Breast cancer

KW - Growth arrest

KW - MDA-MB-231

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Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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