Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men

Samar R. El Khoudary, Emma Barinas-Mitchell, Jessica White, Kim Sutton-Tyrrell, Lewis H. Kuller, J. David Curb, Chol Shin, Hirotsugu Ueshima, Kamal Masaki, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Akira Sekikawa

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Objective: Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several risk factors as possible independent predictors of aortic stiffness progression among a population-based sample of US men. Methods: A total of 240 men (40-49 years) free of CVD at baseline from the Pittsburgh site of the ERA JUMP study were evaluated. Aortic stiffness was measured as carotid-femoral pulse wave velocity at baseline and after 4.6 ± 0.2 (mean ± SD) years of follow-up. Progression of aortic stiffness was evaluated as relative annual change in carotid-femoral pulse wave velocity (% change/year). Using linear regression, both baseline potential risk factors and their annual changes were evaluated as possible risk factors for aortic stiffness progression. Baseline age, follow-up time, race, heart rate, and medications use were forced in all models. Results: During follow-up, relative to baseline level, aortic stiffness increased 0.3% ± 5.3% per year. In final models, the independent predictors of degree of aortic stiffness progression were lower levels of adiponectin (P = 0.03), higher levels of systolic blood pressure (P = 0.03), greater annual change in systolic blood pressure (P = 0.04), and alcohol consumption ≥ 2 times/week (P = 0.02). Adiponectin levels within the third (9.8 μg/Ml ≤ adiponectin < 13.0 μg/mL) and the fourth (adiponectin ≥ 13.0 μg/mL) quartiles were associated with an improvement in relative annual aortic stiffness progression (P = 0.02, P = 0.01, respectively) compared to levels within the first quartile (adiponectin ≤ 7.0 μg/mL). Conclusion: Among apparently healthy men, lower levels of baseline adiponectin could be a novel marker for greater risk of aortic stiffness progression. Longitudinal research is required to evaluate whether adiponectin change over time would have similar association with aortic stiffness progression.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
Issue number2
Publication statusPublished - 2012 Dec

Bibliographical note

Funding Information:
This research was supported by grants R01 HL68200 and HL071561 from the NIH as well as B 16790335 and A 13307016 , 17209023 , and 21249043 from the Japanese Ministry of Education, Culture, Sports, Science and Technology .


  • Arteriosclerosis
  • Hypertension
  • Pulse wave velocity
  • Risk factors
  • Stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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