Abstract
We recently established an adrenal clock-disrupted transgenic mouse line (BMAS) that exhibits a dampened rhythm of corticosterone secretion and reduced amplitude of day/night activity. Here, we observe that voluntary wheel running increases the robustness and amplitude of both body temperature and home cage activity (HCA) rhythms in wild-type, but not in BMAS mice, but without affecting estrous cycle. Surprisingly, wheel running alters the HCA waveform of BMAS females in a way that preferentially increases the late nighttime (ZT21-ZT24) HCA. These results indicate that adrenal clock disruption causes the animals to respond differently to the voluntary exercise cue in middle-aged female mice.
Original language | English |
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Pages (from-to) | 397-405 |
Number of pages | 9 |
Journal | Animal Cells and Systems |
Volume | 17 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2013 |
Bibliographical note
Funding Information:This work was supported by a grant funded by Kyung Hee University (No. 20090604).
Keywords
- adrenal clock
- biological rhythm
- body temperature
- exercise
- home cage activity
- middle-aged female mouse
ASJC Scopus subject areas
- Animal Science and Zoology
- Biochemistry, Genetics and Molecular Biology(all)