Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice

Tae Soo Kim, Dong Hee Han, Yeon Ju Lee, Gi Hoon Son, Kyungjin Kim, Chang Ju Kim, Sehyung Cho

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We recently established an adrenal clock-disrupted transgenic mouse line (BMAS) that exhibits a dampened rhythm of corticosterone secretion and reduced amplitude of day/night activity. Here, we observe that voluntary wheel running increases the robustness and amplitude of both body temperature and home cage activity (HCA) rhythms in wild-type, but not in BMAS mice, but without affecting estrous cycle. Surprisingly, wheel running alters the HCA waveform of BMAS females in a way that preferentially increases the late nighttime (ZT21-ZT24) HCA. These results indicate that adrenal clock disruption causes the animals to respond differently to the voluntary exercise cue in middle-aged female mice.

    Original languageEnglish
    Pages (from-to)397-405
    Number of pages9
    JournalAnimal Cells and Systems
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Bibliographical note

    Funding Information:
    This work was supported by a grant funded by Kyung Hee University (No. 20090604).

    Keywords

    • adrenal clock
    • biological rhythm
    • body temperature
    • exercise
    • home cage activity
    • middle-aged female mouse

    ASJC Scopus subject areas

    • Animal Science and Zoology
    • General Biochemistry,Genetics and Molecular Biology

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