Abstract
Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetesaccelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and on discovering drugs to prevent the progression of AGE-induced maladies.
Original language | English |
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Pages (from-to) | 1131-1138 |
Number of pages | 8 |
Journal | Food Science and Biotechnology |
Volume | 17 |
Issue number | 6 |
Publication status | Published - 2008 |
Keywords
- Advanced glycation endproduct
- Diabetes mellitus
- Diabetic complication
- Inhibitor
- Reactive oxygen species (ros)
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology