Adverse Events with Sustained-Release Donepezil in Alzheimer Disease

Chunsoo Lee; Kyungsang Lee; Hyewon Yu; Seung Ho Ryu; Seok Woo Moon; Changsu Han; Jun Young Lee; Young Min Lee; Shin Gyeom Kim; Ki Woong Kim; Dong Woo Lee; Seong Yoon Kim; Sang Yeol Lee; Jae Nam Bae; Young Eun Jung; Jeong Lan Kim; Byung Soo Kim; Il Seon Shin; Young Hoon Kim; Bong Jo Kim; Hyo Shin; Woojae Myung; Bernard J. Carroll; Doh Kwan Kim

doi:10.1097/JCP.0000000000000726

Adverse Events with Sustained-Release Donepezil in Alzheimer Disease

Chunsoo Lee, Kyungsang Lee, Hyewon Yu, Seung Ho Ryu, Seok Woo Moon, Changsu Han, Jun Young Lee, Young Min Lee, Shin Gyeom Kim, Ki Woong Kim, Dong Woo Lee, Seong Yoon Kim, Sang Yeol Lee, Jae Nam Bae, Young Eun Jung, Jeong Lan Kim, Byung Soo Kim, Il Seon Shin, Young Hoon Kim, Bong Jo KimHyo Shin, Woojae Myung, Bernard J. Carroll, Doh Kwan Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Purpose/Background: Sustained-releasehigh-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trialbody weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. Methods/Procedures: To clarify whether this finding is consistent across ethnic groups that vary in absolute body masswe recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10mg/d for at least 3months.

Original language	English
Pages (from-to)	401-404
Number of pages	4
Journal	Journal of Clinical Psychopharmacology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1097/JCP.0000000000000726
Publication status	Published - 2017 Aug 1
Externally published	Yes

Keywords

Alzheimer disease
adverse effects
body mass index
clinical trial
donepezil

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JCP.0000000000000726

Cite this

Lee, C., Lee, K., Yu, H., Ryu, S. H., Moon, S. W., Han, C., Lee, J. Y., Lee, Y. M., Kim, S. G., Kim, K. W., Lee, D. W., Kim, S. Y., Lee, S. Y., Bae, J. N., Jung, Y. E., Kim, J. L., Kim, B. S., Shin, I. S., Kim, Y. H., ... Kim, D. K. (2017). Adverse Events with Sustained-Release Donepezil in Alzheimer Disease. Journal of Clinical Psychopharmacology, 37(4), 401-404. https://doi.org/10.1097/JCP.0000000000000726

Lee, C, Lee, K, Yu, H, Ryu, SH, Moon, SW, Han, C, Lee, JY, Lee, YM, Kim, SG, Kim, KW, Lee, DW, Kim, SY, Lee, SY, Bae, JN, Jung, YE, Kim, JL, Kim, BS, Shin, IS, Kim, YH, Kim, BJ, Shin, H, Myung, W, Carroll, BJ & Kim, DK 2017, 'Adverse Events with Sustained-Release Donepezil in Alzheimer Disease', Journal of Clinical Psychopharmacology, vol. 37, no. 4, pp. 401-404. https://doi.org/10.1097/JCP.0000000000000726

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abstract = "Purpose/Background: Sustained-releasehigh-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trialbody weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. Methods/Procedures: To clarify whether this finding is consistent across ethnic groups that vary in absolute body masswe recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10mg/d for at least 3months.",

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author = "Chunsoo Lee and Kyungsang Lee and Hyewon Yu and Ryu, {Seung Ho} and Moon, {Seok Woo} and Changsu Han and Lee, {Jun Young} and Lee, {Young Min} and Kim, {Shin Gyeom} and Kim, {Ki Woong} and Lee, {Dong Woo} and Kim, {Seong Yoon} and Lee, {Sang Yeol} and Bae, {Jae Nam} and Jung, {Young Eun} and Kim, {Jeong Lan} and Kim, {Byung Soo} and Shin, {Il Seon} and Kim, {Young Hoon} and Kim, {Bong Jo} and Hyo Shin and Woojae Myung and Carroll, {Bernard J.} and Kim, {Doh Kwan}",

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AU - Lee, Chunsoo

AU - Lee, Kyungsang

AU - Yu, Hyewon

AU - Ryu, Seung Ho

AU - Moon, Seok Woo

AU - Han, Changsu

AU - Lee, Jun Young

AU - Lee, Young Min

AU - Kim, Shin Gyeom

AU - Kim, Ki Woong

AU - Lee, Dong Woo

AU - Kim, Seong Yoon

AU - Lee, Sang Yeol

AU - Bae, Jae Nam

AU - Jung, Young Eun

AU - Kim, Jeong Lan

AU - Kim, Byung Soo

AU - Shin, Il Seon

AU - Kim, Young Hoon

AU - Kim, Bong Jo

AU - Shin, Hyo

AU - Myung, Woojae

AU - Carroll, Bernard J.

AU - Kim, Doh Kwan

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N2 - Purpose/Background: Sustained-releasehigh-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trialbody weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. Methods/Procedures: To clarify whether this finding is consistent across ethnic groups that vary in absolute body masswe recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10mg/d for at least 3months.

AB - Purpose/Background: Sustained-releasehigh-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trialbody weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. Methods/Procedures: To clarify whether this finding is consistent across ethnic groups that vary in absolute body masswe recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10mg/d for at least 3months.

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Adverse Events with Sustained-Release Donepezil in Alzheimer Disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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