Aerogel-Based Biomaterials for Biomedical Applications: From Fabrication Methods to Disease-Targeting Applications

Solmaz Karamikamkar, Ezgi Pinar Yalcintas, Reihaneh Haghniaz, Natan Roberto de Barros, Marvin Mecwan, Rohollah Nasiri, Elham Davoodi, Fatemeh Nasrollahi, Ahmet Erdem, Heemin Kang, Junmin Lee, Yangzhi Zhu, Samad Ahadian, Vadim Jucaud, Hajar Maleki, Mehmet Remzi Dokmeci, Han Jun Kim, Ali Khademhosseini

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Aerogel-based biomaterials are increasingly being considered for biomedical applications due to their unique properties such as high porosity, hierarchical porous network, and large specific pore surface area. Depending on the pore size of the aerogel, biological effects such as cell adhesion, fluid absorption, oxygen permeability, and metabolite exchange can be altered. Based on the diverse potential of aerogels in biomedical applications, this paper provides a comprehensive review of fabrication processes including sol-gel, aging, drying, and self-assembly along with the materials that can be used to form aerogels. In addition to the technology utilizing aerogel itself, it also provides insight into the applicability of aerogel based on additive manufacturing technology. To this end, how microfluidic-based technologies and 3D printing can be combined with aerogel-based materials for biomedical applications is discussed. Furthermore, previously reported examples of aerogels for regenerative medicine and biomedical applications are thoroughly reviewed. A wide range of applications with aerogels including wound healing, drug delivery, tissue engineering, and diagnostics are demonstrated. Finally, the prospects for aerogel-based biomedical applications are presented. The understanding of the fabrication, modification, and applicability of aerogels through this study is expected to shed light on the biomedical utilization of aerogels.

Original languageEnglish
Article number2204681
JournalAdvanced Science
Volume10
Issue number23
DOIs
Publication statusPublished - 2023 Aug 15

Bibliographical note

Funding Information:
The authors gratefully acknowledge the funding by the National Institutes of Health (HL140951, HL137193, CA257558, DK130566). S.K. gratefully acknowledges the support of the Natural Sciences and Engineering Research Council of Canada (NSERC – PDF – 557699 – 2021). F.N. acknowledges the Schlumberger Foundation, Faculty for the Future fellowship. H.M. acknowledges the German research foundation, Deutsche Forschungsgemeinschaft (DFG) – Projektnummer 467116484.

Publisher Copyright:
© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

Keywords

  • additive manufacturing
  • aerogel
  • diagnosis
  • drug delivery
  • microfluidics
  • tissue engineering
  • wound healing

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • General Chemical Engineering
  • General Materials Science
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Engineering
  • General Physics and Astronomy

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