Age and sex dependent association of uric acid and incident hypertension

Woohyeun Kim, Tae Hwa Go, Dong Oh Kang, Jieun Lee, Jah Yeon Choi, Seung Young Roh, Jin Oh Na, Cheol Ung Choi, Seung Woon Rha, Chang Gyu Park, Hong Seog Seo, Dae Ryong Kang, Jang Young Kim, Eung Ju Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background and aims: A previous meta-analysis suggested that the relationship between hyperuricemia and hypertension may be stronger in younger individuals and women. We aimed to investigate the age and sex dependent association of uric acid (UA) and incident hypertension. Methods and results: We analyzed data from the Health Examinees Study, a community-based prospective cohort study conducted in Korea from 2004 to 2013. It included 29,088 non-hypertensive subjects aged 40–79 (age, 52.5 ± 7.8 years; men, 31.4%) who had serum UA measurement and participated in the follow-up survey. The risk factors of hypertension were assessed using Cox regression. Over a mean 3.8 years of follow-up, 1388 men (15.2%) and 1942 women (9.7%) were newly diagnosed with hypertension. Upon age- and sex-based stratification, the risk of hypertension was highest in hyperuricemic subjects aged 40–49 years (HR: women, 2.16; men, 1.30). Across the entire cohort, the risk of incident hypertension was higher in groups with higher serum UA levels, and highest in women aged 40–49 years (HR, 1.44; P < 0.001). On multivariable linear regression analysis, the higher the baseline serum UA level, the greater the increase in blood pressure during follow-up, and this effect was strongest in women aged 40–49 years (β = 0.87 and P < 0.01 for systolic blood pressure). Conclusions: The relationship between uric acid and incident hypertension tended to be dependent on age and sex. Younger women are at highest risk of UA-related incident hypertension.

Original languageEnglish
Pages (from-to)1200-1208
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number4
Publication statusPublished - 2021 Apr 9

Bibliographical note

Funding Information:
This study was funded by the Korea Health Industry Development Institute (KHIDI) and the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0483 ), and supported by the Technology Innovation Program, funded by the Ministry of Trade, Industry & Energy (MOTIE , Korea, Grant No: 20001234 ).

Funding Information:
This work was supported by the Research Program of the Korea Centers for Disease Control and Prevention and Korean Society of Cardiometabolic Syndrome.

Publisher Copyright:
© 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University


  • Hypertension
  • Hyperuricemia
  • Uric acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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