Age-dependent changes in the subcallosal zone neurogenesis of mice

Hyun Jung Kim, Joo Yeon Kim, Woong Sun

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


There are several known neurogenic areas including subventricular zone and subgranular layer in the dentate gyrus of the hippocampus. Both germinal centers exhibit an age-dependent decline in cell proliferation and neurogenesis, which may be associated with age-related decline in brain function. We recently identified the subcallosal zone (SCZ) as a novel neural stem cell niche with a potential to spontaneously produce new neuroblasts. We examined whether SCZ neurogenesis is also regulated by the age of mice. The number of newly generated neuroblasts was reduced in the SCZ with age, and only marginal number of DCX-labeled neuroblasts was found in 6-month-old SCZ, which is most likely due to reduced proliferation of progenitor cells and loss of neural stem cells (NSCs). This age-dependent changes in the SCZ occurred earlier than that of other neurogenic brain regions. The neurosphere assay in vitro confirmed the depletion of NSCs within the SCZ of young adults. However, marked induction of neuroblast production in the SCZ was seen in 6-month-old mice after traumatic brain injury. Taken together, these results indicate that a rapid decline in SCZ neurogenesis in mice is due to depletion of NSCs and reduced capacity to produce neuroblasts.

Original languageEnglish
Pages (from-to)879-884
Number of pages6
JournalNeurochemistry International
Issue number6
Publication statusPublished - 2012 Nov

Bibliographical note

Funding Information:
This work is supported by the National Research Foundation of Korea (NRF) Grants funded by the Korea Government ( 20110019409 , 20110019212 ).


  • Aging
  • Neural stem cell
  • Neurogenesis
  • Subcallosal zone
  • Traumatic brain injury

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology


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