Ageing with elegans: a research proposal to map healthspan pathways

Walter Luyten; Peter Antal; Bart P. Braeckman; Jake Bundy; Francesca Cirulli; Christopher Fang-Yen; Georg Fuellen; Armand Leroi; Qingfei Liu; Patricia Martorell; Andres Metspalu; Markus Perola; Michael Ristow; Nadine Saul; Liliane Schoofs; Karsten Siems; Liesbet Temmerman; Tina Smets; Alicja Wolk; Suresh I.S. Rattan

doi:10.1007/s10522-016-9644-x

Ageing with elegans: a research proposal to map healthspan pathways

Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I.S. Rattan

College of Science

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority (http://www.healthyageing.eu/european-policies-and-initiatives); it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme (https://ec.europa.eu/programmes/horizon2020/en/h2020-section/health-demographic-change-and-wellbeing), which has launched several research and innovation actions (RIA), like “Understanding health, ageing and disease: determinants, risk factors and pathways” in the work programme on “Personalising healthcare” (https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/693-phc-01-2014.html). Here we present our research proposal entitled “ageing with elegans” (AwE) (http://www.h2020awe.eu/), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism.

Original language	English
Pages (from-to)	771-782
Number of pages	12
Journal	Biogerontology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1007/s10522-016-9644-x
Publication status	Published - 2016 Aug 1

Bibliographical note

Funding Information:
We would like to thank Dr. Iesel Van der Plancken, Dr. Daniel Ramón, and Dr. Steven Van Vooren for critical comments on the AwE proposal, and Dr. Geert Depuydt and Brecht Wouters (KU Leuven) for help with finalising the manuscript. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant agreement No 633589. This publication reflects only the authors’ views and the Commission is not responsible for any use that may be made of the information it contains.

Publisher Copyright:
© 2016, Springer Science+Business Media Dordrecht.

Keywords

Caenorhabditis elegans
Healthspan
Longevity Nutraceuticals
Medicinal plants
Natural products

ASJC Scopus subject areas

Ageing
Gerontology
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10522-016-9644-x

Cite this

Luyten, W., Antal, P., Braeckman, B. P., Bundy, J., Cirulli, F., Fang-Yen, C., Fuellen, G., Leroi, A., Liu, Q., Martorell, P., Metspalu, A., Perola, M., Ristow, M., Saul, N., Schoofs, L., Siems, K., Temmerman, L., Smets, T., Wolk, A., & Rattan, S. I. S. (2016). Ageing with elegans: a research proposal to map healthspan pathways. Biogerontology, 17(4), 771-782. https://doi.org/10.1007/s10522-016-9644-x

Luyten, W, Antal, P, Braeckman, BP, Bundy, J, Cirulli, F, Fang-Yen, C, Fuellen, G, Leroi, A, Liu, Q, Martorell, P, Metspalu, A, Perola, M, Ristow, M, Saul, N, Schoofs, L, Siems, K, Temmerman, L, Smets, T, Wolk, A & Rattan, SIS 2016, 'Ageing with elegans: a research proposal to map healthspan pathways', Biogerontology, vol. 17, no. 4, pp. 771-782. https://doi.org/10.1007/s10522-016-9644-x

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abstract = "Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority (http://www.healthyageing.eu/european-policies-and-initiatives); it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme (https://ec.europa.eu/programmes/horizon2020/en/h2020-section/health-demographic-change-and-wellbeing), which has launched several research and innovation actions (RIA), like “Understanding health, ageing and disease: determinants, risk factors and pathways” in the work programme on “Personalising healthcare” (https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/693-phc-01-2014.html). Here we present our research proposal entitled “ageing with elegans” (AwE) (http://www.h2020awe.eu/), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism.",

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AU - Fuellen, Georg

AU - Leroi, Armand

AU - Liu, Qingfei

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AU - Metspalu, Andres

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N2 - Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority (http://www.healthyageing.eu/european-policies-and-initiatives); it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme (https://ec.europa.eu/programmes/horizon2020/en/h2020-section/health-demographic-change-and-wellbeing), which has launched several research and innovation actions (RIA), like “Understanding health, ageing and disease: determinants, risk factors and pathways” in the work programme on “Personalising healthcare” (https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/693-phc-01-2014.html). Here we present our research proposal entitled “ageing with elegans” (AwE) (http://www.h2020awe.eu/), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism.

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Ageing with elegans: a research proposal to map healthspan pathways

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this