All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

Jung Min Lee, Dingchang Lin, Ha Reem Kim, Young Woo Pyo, Guosong Hong, Charles M. Lieber, Hong Gyu Park

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.

Original languageEnglish
Pages (from-to)3184-3190
Number of pages7
JournalNano Letters
Issue number7
Publication statusPublished - 2021 Apr 14

Bibliographical note

Publisher Copyright:
© 2021 American Chemical Society.


  • biocompatible optogenetic probes
  • chronic neural interface
  • flexible waveguide
  • injectable mesh electronics
  • optogenetics

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


Dive into the research topics of 'All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping'. Together they form a unique fingerprint.

Cite this