Allelic variants interaction of CLOCK gene and G-protein β3 subunit gene with diurnal preference

Heon Jeong Lee, Jong Woo Paik, Seung Gul Kang, Se Won Lim, Leen Kim

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The 3111 C/T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C/T SNP in the G-protein β3 subunit gene (GNB3) have been reported to influence diurnal preference. This study has attempted to characterize the association between the CLOCK gene and GNB3 polymorphisms and diurnal preference in healthy Korean college students. All subjects completed the 13-item Composite Scale for Morningness (CSM). The interaction between the 3111 C/T SNP in the CLOCK gene and the 825 C/T SNP in the GNB3 gene significantly influenced diurnal preference, according to the CSM Performance subscore (F=10.94, p=0.001). However, when the different polymorphisms of the two genes were analyzed independently, no direct correlations with diurnal preference were detected. The CLOCK gene 3111 C/T SNP and GNB3 gene 825 C/T SNP were found to manifest a gene-gene interaction that affects diurnal preference.

Original languageEnglish
Pages (from-to)589-597
Number of pages9
JournalChronobiology International
Issue number4
Publication statusPublished - 2007 Jul

Bibliographical note

Funding Information:
This work was partially supported by the Byung-Yoon Lee Memorial Grant from the Korea University Neuropsychiatric Alumni Association.

Copyright 2008 Elsevier B.V., All rights reserved.


  • CLOCK gene
  • Diurnal preference
  • Epistasis
  • G-protein β3 subunit gene
  • Morningness-eveningness

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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