Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population

Heon Jeong Lee; Hong Seock Lee; Yong Ku Kim; Seung Hyun Kim; Leen Kim; Min Soo Lee; Sook Haeng Joe; In Kwa Jung; Kwang Yoon Suh; Sangduk Kim

doi:10.1002/ajmg.b.10047

Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population

Heon Jeong Lee, Hong Seock Lee, Yong Ku Kim, Seung Hyun Kim, Leen Kim, Min Soo Lee, Sook Haeng Joe, In Kwa Jung, Kwang Yoon Suh, Sangduk Kim

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young (≈14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and - 521 C/T, there was no direct correlation with the personality traits.

Original language	English
Pages (from-to)	76-80
Number of pages	5
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	118 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.10047
Publication status	Published - 2003 Apr 1

Keywords

DRD4
Novelty seeking
Persistence
Polymorphism

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.10047

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Lee, H. J., Lee, H. S., Kim, Y. K., Kim, S. H., Kim, L., Lee, M. S., Joe, S. H., Jung, I. K., Suh, K. Y., & Kim, S. (2003). Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population. American Journal of Medical Genetics - Neuropsychiatric Genetics, 118 B(1), 76-80. https://doi.org/10.1002/ajmg.b.10047

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abstract = "Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young (≈14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and - 521 C/T, there was no direct correlation with the personality traits.",

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AU - Lee, Heon Jeong

AU - Lee, Hong Seock

AU - Kim, Yong Ku

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AU - Kim, Leen

AU - Lee, Min Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Suh, Kwang Yoon

AU - Kim, Sangduk

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N2 - Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young (≈14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and - 521 C/T, there was no direct correlation with the personality traits.

AB - Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young (≈14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and - 521 C/T, there was no direct correlation with the personality traits.

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Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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