Alteration in Effects of Endometriosis on Fecundity According to Pregnancy Experience in Mouse Model

Wonhyoung Park, Miji Kim, Hee Seung Kim, Gwonhwa Song, Soo Jin Park, Whasun Lim, Sunwoo Park

Research output: Contribution to journalArticlepeer-review


This study is aimed at identifying variations in the effect of endometriosis on fecundity in a mouse model based on prior pregnancy experience. Endometriosis is one of the most prevalent gynecological diseases and is known to impact female fecundity adversely. In this study, an endometriosis mouse model was established by allografting uterine horn tissue using Pelch’s method. The effect of endometriosis on fecundity was confirmed in primiparous and multiparous female mice. As fecundity indicators, the pregnancy rate, number of litters, pregnancy period, and survival rate of the pups were investigated. As a result of the experiment, the pregnancy rate decreased, and the pregnancy period tended to be shorter in primiparous female mice. However, there was no significant change in the multiparous mice. In addition, it has been established that correlations exist between the size of lesions and certain fecundity indicators of the lesion, even among primiparous and multiparous females with endometriosis. The study attempted to demonstrate a link between pregnancy experience and fecundity changes caused by endometriosis by experimentally reproducing clinical results using mouse models. These results suggest strategies for identifying several pathophysiological characteristics of endometriosis.

Original languageEnglish
Pages (from-to)404-412
Number of pages9
JournalReproductive Sciences
Issue number2
Publication statusPublished - 2024 Feb

Bibliographical note

Publisher Copyright:
© 2024, The Author(s), under exclusive licence to Society for Reproductive Investigation.


  • Endometriosis
  • Fecundity
  • Pregnancy
  • Pregnancy experience

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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