Alteration of extracellular matrix modulators after nonablative laser therapy in skin rejuvenation

J. Oh; N. Kim; S. Seo; I. H. Kim

doi:10.1111/j.1365-2133.2007.08061.x

Alteration of extracellular matrix modulators after nonablative laser therapy in skin rejuvenation

J. Oh, N. Kim, S. Seo, I. H. Kim

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background: Nonablative laser therapy is widely practised for skin rejuvenation, which stimulates collagen production and dermal matrix remodelling. Matrix remodelling is primarily modulated by a coordinated action of matrix metalloproteinases (MMPs) and their inhibitors, but the effects of nonablative lasers on these matrix modulators are not fully investigated. Objectives: To evaluate the changes in matrix modulators, such as MMP-1, MMP-2, MMP-3, MMP-9 and MT1-MMP, and their inhibitors (TIMP-1, TIMP-2 and RECK in particular), after nonablative laser treatments of human facial skin. Methods: Twenty-four adult volunteers received a series of four nonablative laser treatments separated by 3-week intervals on facial skin. Two-millimetre skin punch biopsies were obtained at baseline and 3 weeks after the last treatment. Results: Nonablative laser treatments led to a robust increase in two major dermal matrix components, type I collagen and tropoelastin. Among MMPs tested, levels of MMP-2 mRNA were statistically significantly increased, but the amount of active MMP-2 was rather reduced. More importantly, the expression level of RECK was significantly enhanced by laser treatments. Conclusions: Clinical outcomes following nonablative laser treatments may result not only from increased biosynthesis but also from decreased degradation, via an induction of RECK expression, of matrix proteins.

Original language	English
Pages (from-to)	306-310
Number of pages	5
Journal	British Journal of Dermatology
Volume	157
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2133.2007.08061.x
Publication status	Published - 2007 Aug

Bibliographical note

Funding Information:
The behavioral abnormalities constituting the alcohol withdrawal reaction have been considered to reflect the release of a latent state of increased neural excitability developed as a result of continuous exposure to alcohol (Kalant et al., 1971). There exists at present little direct evidence regarding the involvement of specific brain regions in the development of the neural hyperexcitability. One technique that has not been effectively utilized is the recording of electrographic (EEG) activity during the withdrawal reaction. Wikler et al. (1956) in studies of the alcohol withdrawal syndrome in man characterized the EEG abnormalities as mild in comparison to those of barbiturate withdrawal, thereby implicating subcortical regions in the genesis of the withdrawal reaction. In preliminary studies in alcohol-dependent mice {Walker and Zornetzer 1974) and rats (Hunter et al. 1973) we observed a progressive development of epileptiform abnormalities from chronically implanted depth electrodes in a variety of forebrain regions. The widespread nature of forebrain involvement in abnormal patterns of EEG activity suggested two alter- I This work was supported by the Veterans Adminis-tration and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Grant No. AA-00200 to D.W.W.B.E.H. was supported by NIAAA Predoc-total Fellowship No. AA-05022 and J.N.R. was sup-ported by NIAAA Predoctoral Fellowship No. AA-05029.

Keywords

Extracellular matrix
Matrix metalloproteinases
Nonablative laser
RECK
Tissue inhibitors of metalloproteinases

ASJC Scopus subject areas

Dermatology

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10.1111/j.1365-2133.2007.08061.x

Cite this

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title = "Alteration of extracellular matrix modulators after nonablative laser therapy in skin rejuvenation",

abstract = "Background: Nonablative laser therapy is widely practised for skin rejuvenation, which stimulates collagen production and dermal matrix remodelling. Matrix remodelling is primarily modulated by a coordinated action of matrix metalloproteinases (MMPs) and their inhibitors, but the effects of nonablative lasers on these matrix modulators are not fully investigated. Objectives: To evaluate the changes in matrix modulators, such as MMP-1, MMP-2, MMP-3, MMP-9 and MT1-MMP, and their inhibitors (TIMP-1, TIMP-2 and RECK in particular), after nonablative laser treatments of human facial skin. Methods: Twenty-four adult volunteers received a series of four nonablative laser treatments separated by 3-week intervals on facial skin. Two-millimetre skin punch biopsies were obtained at baseline and 3 weeks after the last treatment. Results: Nonablative laser treatments led to a robust increase in two major dermal matrix components, type I collagen and tropoelastin. Among MMPs tested, levels of MMP-2 mRNA were statistically significantly increased, but the amount of active MMP-2 was rather reduced. More importantly, the expression level of RECK was significantly enhanced by laser treatments. Conclusions: Clinical outcomes following nonablative laser treatments may result not only from increased biosynthesis but also from decreased degradation, via an induction of RECK expression, of matrix proteins.",

keywords = "Extracellular matrix, Matrix metalloproteinases, Nonablative laser, RECK, Tissue inhibitors of metalloproteinases",

author = "J. Oh and N. Kim and S. Seo and Kim, {I. H.}",

note = "Funding Information: The behavioral abnormalities constituting the alcohol withdrawal reaction have been considered to reflect the release of a latent state of increased neural excitability developed as a result of continuous exposure to alcohol (Kalant et al., 1971). There exists at present little direct evidence regarding the involvement of specific brain regions in the development of the neural hyperexcitability. One technique that has not been effectively utilized is the recording of electrographic (EEG) activity during the withdrawal reaction. Wikler et al. (1956) in studies of the alcohol withdrawal syndrome in man characterized the EEG abnormalities as mild in comparison to those of barbiturate withdrawal, thereby implicating subcortical regions in the genesis of the withdrawal reaction. In preliminary studies in alcohol-dependent mice {Walker and Zornetzer 1974) and rats (Hunter et al. 1973) we observed a progressive development of epileptiform abnormalities from chronically implanted depth electrodes in a variety of forebrain regions. The widespread nature of forebrain involvement in abnormal patterns of EEG activity suggested two alter- I This work was supported by the Veterans Adminis-tration and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Grant No. AA-00200 to D.W.W.B.E.H. was supported by NIAAA Predoc-total Fellowship No. AA-05022 and J.N.R. was sup-ported by NIAAA Predoctoral Fellowship No. AA-05029.",

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journal = "British Journal of Dermatology",

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T1 - Alteration of extracellular matrix modulators after nonablative laser therapy in skin rejuvenation

AU - Oh, J.

AU - Kim, N.

AU - Seo, S.

AU - Kim, I. H.

N1 - Funding Information: The behavioral abnormalities constituting the alcohol withdrawal reaction have been considered to reflect the release of a latent state of increased neural excitability developed as a result of continuous exposure to alcohol (Kalant et al., 1971). There exists at present little direct evidence regarding the involvement of specific brain regions in the development of the neural hyperexcitability. One technique that has not been effectively utilized is the recording of electrographic (EEG) activity during the withdrawal reaction. Wikler et al. (1956) in studies of the alcohol withdrawal syndrome in man characterized the EEG abnormalities as mild in comparison to those of barbiturate withdrawal, thereby implicating subcortical regions in the genesis of the withdrawal reaction. In preliminary studies in alcohol-dependent mice {Walker and Zornetzer 1974) and rats (Hunter et al. 1973) we observed a progressive development of epileptiform abnormalities from chronically implanted depth electrodes in a variety of forebrain regions. The widespread nature of forebrain involvement in abnormal patterns of EEG activity suggested two alter- I This work was supported by the Veterans Adminis-tration and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) Grant No. AA-00200 to D.W.W.B.E.H. was supported by NIAAA Predoc-total Fellowship No. AA-05022 and J.N.R. was sup-ported by NIAAA Predoctoral Fellowship No. AA-05029.

PY - 2007/8

Y1 - 2007/8

N2 - Background: Nonablative laser therapy is widely practised for skin rejuvenation, which stimulates collagen production and dermal matrix remodelling. Matrix remodelling is primarily modulated by a coordinated action of matrix metalloproteinases (MMPs) and their inhibitors, but the effects of nonablative lasers on these matrix modulators are not fully investigated. Objectives: To evaluate the changes in matrix modulators, such as MMP-1, MMP-2, MMP-3, MMP-9 and MT1-MMP, and their inhibitors (TIMP-1, TIMP-2 and RECK in particular), after nonablative laser treatments of human facial skin. Methods: Twenty-four adult volunteers received a series of four nonablative laser treatments separated by 3-week intervals on facial skin. Two-millimetre skin punch biopsies were obtained at baseline and 3 weeks after the last treatment. Results: Nonablative laser treatments led to a robust increase in two major dermal matrix components, type I collagen and tropoelastin. Among MMPs tested, levels of MMP-2 mRNA were statistically significantly increased, but the amount of active MMP-2 was rather reduced. More importantly, the expression level of RECK was significantly enhanced by laser treatments. Conclusions: Clinical outcomes following nonablative laser treatments may result not only from increased biosynthesis but also from decreased degradation, via an induction of RECK expression, of matrix proteins.

AB - Background: Nonablative laser therapy is widely practised for skin rejuvenation, which stimulates collagen production and dermal matrix remodelling. Matrix remodelling is primarily modulated by a coordinated action of matrix metalloproteinases (MMPs) and their inhibitors, but the effects of nonablative lasers on these matrix modulators are not fully investigated. Objectives: To evaluate the changes in matrix modulators, such as MMP-1, MMP-2, MMP-3, MMP-9 and MT1-MMP, and their inhibitors (TIMP-1, TIMP-2 and RECK in particular), after nonablative laser treatments of human facial skin. Methods: Twenty-four adult volunteers received a series of four nonablative laser treatments separated by 3-week intervals on facial skin. Two-millimetre skin punch biopsies were obtained at baseline and 3 weeks after the last treatment. Results: Nonablative laser treatments led to a robust increase in two major dermal matrix components, type I collagen and tropoelastin. Among MMPs tested, levels of MMP-2 mRNA were statistically significantly increased, but the amount of active MMP-2 was rather reduced. More importantly, the expression level of RECK was significantly enhanced by laser treatments. Conclusions: Clinical outcomes following nonablative laser treatments may result not only from increased biosynthesis but also from decreased degradation, via an induction of RECK expression, of matrix proteins.

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KW - Tissue inhibitors of metalloproteinases

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Alteration of extracellular matrix modulators after nonablative laser therapy in skin rejuvenation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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