TY - JOUR
T1 - Altered brain network modules induce helplessness in major depressive disorder
AU - Peng, Daihui
AU - Shi, Feng
AU - Shen, Ting
AU - Peng, Ziwen
AU - Zhang, Chen
AU - Liu, Xiaohua
AU - Qiu, Meihui
AU - Liu, Jun
AU - Jiang, Kaida
AU - Fang, Yiru
AU - Shen, Dinggang
N1 - Funding Information:
This work was supported by Science Fund of Shanghai Jiao Tong University (Grant nos. 11XJ21006 and YG2012MS11 ), Fund of Science and Technology Commission of Shanghai Municipality (Grant no. 134119a6200 ), Overseas Talent Project of Shanghai health bureau (Grant no. GWHW201208 ), the “12th Five-year Plan” of National Key Technologies R&D Program (Grant no. 2012BAI01B04 ), National Natural Science Foundation of China, China (Grant nos. 81201049 and 91232719 ). In addition, this grant is also partially supported by NIH grants (Grant nos. EB006733 , EB008374 , EB009634 , AG041721 , MH100217 , and AG042599 ).
PY - 2014/10/15
Y1 - 2014/10/15
N2 - Objective The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD. Methods Resting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDD patients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDD patients were measured to reflect the regional roles in module network, and the impairment of FC was examined by network based statistic. Results Small-world property was not altered in MDD. However, MDD patients exhibited 5 atypically reorganized modules compared to the controls. A positive relationship was also found among MDD patients between the intra-module I and helplessness factor evaluated via the Hamilton Depression Scale. Specifically, eight regions exhibited the abnormal participant coefficient or module degree, e.g., left superior orbital frontal cortex and right amygdala. The decreased FC was identified among the sub-network of 24 brain regions, e.g., frontal cortex, supplementary motor area, amygdala, thalamus, and hippocampus. Limitation The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC. Conclusions The results revealed altered patterns of brain module network at the global level in MDD patients, which might contribute to the feelings of helplessness.
AB - Objective The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD. Methods Resting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDD patients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDD patients were measured to reflect the regional roles in module network, and the impairment of FC was examined by network based statistic. Results Small-world property was not altered in MDD. However, MDD patients exhibited 5 atypically reorganized modules compared to the controls. A positive relationship was also found among MDD patients between the intra-module I and helplessness factor evaluated via the Hamilton Depression Scale. Specifically, eight regions exhibited the abnormal participant coefficient or module degree, e.g., left superior orbital frontal cortex and right amygdala. The decreased FC was identified among the sub-network of 24 brain regions, e.g., frontal cortex, supplementary motor area, amygdala, thalamus, and hippocampus. Limitation The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC. Conclusions The results revealed altered patterns of brain module network at the global level in MDD patients, which might contribute to the feelings of helplessness.
KW - Functional connectivity
KW - Helplessness
KW - Major depressive disorder
KW - Modularity
KW - Small-worldness
UR - http://www.scopus.com/inward/record.url?scp=84904576179&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2014.05.061
DO - 10.1016/j.jad.2014.05.061
M3 - Article
C2 - 25033474
AN - SCOPUS:84904576179
SN - 0165-0327
VL - 168
SP - 21
EP - 29
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -