Altered expression of Notch1 in Alzheimer’s disease

Sun Jung Cho, Sang Moon Yun, Chulman Jo, Jihyun Jeong, Moon Ho Park, Changsu Han, Young Ho Koh

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)


    Notch signaling is an evolutionarily conserved pathway that regulates cell-cell interactions through binding of Notch family receptors to their cognate ligands. Notch signaling has an essential role in vascular development and angiogenesis. Recent studies have reported that Notch may be implicated in Alzheimer’s disease (AD) pathophysiology. We measured the levels of soluble Notch1 (sNotch1) in the plasma samples from 72 dementia patients (average age 75.1 y), 89 subjects with amnestic mild cognitive impairment (MCI) (average age 73.72 y), and 150 cognitively normal controls (average age 72.34 y). Plasma levels of sNotch1 were 25.27% lower in dementia patients as compared to healthy control subjects. However, the level of Notch1 protein was significantly increased in human brain microvascular endothelial cells (HBMECs) after amyloid-beta treatment. Also, Notch1 mRNA level was significantly increased in HBMECs and iPSC-derived neuronal cells from AD patient compared to normal control. These results indicate that altered expression of Notch1 might be associated with the risk of Alzheimer’s disease.

    Original languageEnglish
    Article numbere0224941
    JournalPloS one
    Issue number11
    Publication statusPublished - 2019 Nov 1

    Bibliographical note

    Funding Information:
    All participants were collected and clinically evaluated by Moon Ho Park and Changsu Han from Korea University Ansan Hospital.

    Publisher Copyright:
    © 2019 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    ASJC Scopus subject areas

    • General


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