Altered heart and kidney phospholipid fatty acid composition are associated with cardiac hypertrophy in hypertensive rats

Oh Yoen Kim, Young Sang Jung, Yoonsu Cho, Ji Hyung Chung, Geum Sook Hwang, Min Jeong Shin

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Objective: We examined the association of cardiac hypertrophy or fibrosis with the phospholipid fatty acid (FA) composition of heart and kidney in hypertensive rats. Design and methods: Eight-week-old spontaneously hypertensive rats (SHRs) (n. =. 8) and Wistar Kyoto rats (WKYs, n. =. 8) as a normotensive control, were fed ad libitum for 6. weeks with regular AIN-76 diet. Phospholipid FA compositions in the left ventricle and kidney were measured and histological analyses were performed. Results: Compared with WKYs, SHRs had lower proportions of γ-linolenic acid, α-linolenic acid, eicosadienoic acid, eicosatrienoic acid, dihomo-γ-linoleic acid, docosadienoic acid and nervonic acid in heart, and stearic acid (SA), γ-linolenic acid, and eicosapentaenoic acid (EPA) in kidney. After adjusting for food intake, SHRs still maintained higher proportions of SA, and total saturated FAs in the heart and a lower proportion of eicosapentaenoic acid in the kidney. Additionally, compared with WKYs, SHRs showed larger cardiomyocyte diameters in the left ventricles, indicating cardiac hypertrophy and interstitial fibrosis. Cardiomyocyte diameters also positively correlated with cardiac SA (r. =. 0.550, p. <. 0.05) and negatively with kidney EPA (r. =. -. 0.575, p. <. 0.05). Conclusion: Tissue FA compositions were associated with cardiac hypertrophy in a hypertensive setting, implicating the pathogenic role of tissue FAs in hypertension and related complications.

Original languageEnglish
Pages (from-to)1111-1117
Number of pages7
JournalClinical Biochemistry
Issue number12
Publication statusPublished - 2013 Aug

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2012-0002119 ), the Creative Allied Project (CAP) grant funded by the Korea Research Council of Fundamental Science and Technology (KRCF) and Korea Basic Science Institute ( E33300 ).


  • Cardiac hypertrophy
  • Fatty acid
  • Hypertension
  • Kidney
  • Left ventricle

ASJC Scopus subject areas

  • Clinical Biochemistry


Dive into the research topics of 'Altered heart and kidney phospholipid fatty acid composition are associated with cardiac hypertrophy in hypertensive rats'. Together they form a unique fingerprint.

Cite this