Alternative Biomarkers for Combined Biology

Yong Hyun Kim, Jennifer Kirsop, Wai Hong Wilson Tang

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)


    Chemotherapy-related cardiac dysfunction (CRCD) has challenged clinicians to hesitate in using cardiotoxic agents such as anthracycline and several protein kinase inhibitors. As early detection of CRCD and timely cessation of cardiotoxic agents became a strategy to avoid CRCD, cardiac troponin and natriuretic peptide are measured to monitor cardiotoxicity; however, there are inconsistencies in their predictability of CRCD. Alternative biomarkers have been researched extensively for potential use as more sensitive and accurate biomarkers. The mechanisms of CRCD and previous studies on traditional and novel biomarkers for CRCD are examined to enlighten future direction of investigation in this combined biology.

    Original languageEnglish
    Pages (from-to)381-401
    Number of pages21
    JournalHeart Failure Clinics
    Issue number2
    Publication statusPublished - 2017 Apr 1


    • Biomarkers
    • Chemotherapy-related cardiac dysfunction
    • Heart failure
    • Malignancy

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine


    Dive into the research topics of 'Alternative Biomarkers for Combined Biology'. Together they form a unique fingerprint.

    Cite this