Abstract
The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.
Original language | English |
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Pages (from-to) | 3517-3520 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 19 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2009 Jul 1 |
Bibliographical note
Funding Information:We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.
Keywords
- Aminoquinolines
- Antiproliferative activity
- Fibroblast cell line
- Melanoma cell line
- Selectivity
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry