Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bong Soo Nam; Hwan Kim; Chang Hyun Oh; So Ha Lee; Seung Joo Cho; Tae Bo Sim; Jung Mi Hah; Dong Jin Kim; Jung Hoon Choi; Kyung Ho Yoo

doi:10.1016/j.bmcl.2009.05.007

Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bong Soo Nam, Hwan Kim, Chang Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung Mi Hah, Dong Jin Kim, Jung Hoon Choi, Kyung Ho Yoo

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC₅₀ = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

Original language	English
Pages (from-to)	3517-3520
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2009.05.007
Publication status	Published - 2009 Jul 1

Bibliographical note

Funding Information:
We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.

Keywords

Aminoquinolines
Antiproliferative activity
Fibroblast cell line
Melanoma cell line
Selectivity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.05.007

Cite this

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title = "Aminoquinoline derivatives with antiproliferative activity against melanoma cell line",

abstract = "The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.",

keywords = "Aminoquinolines, Antiproliferative activity, Fibroblast cell line, Melanoma cell line, Selectivity",

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note = "Funding Information: We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.",

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doi = "10.1016/j.bmcl.2009.05.007",

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T1 - Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

AU - Nam, Bong Soo

AU - Kim, Hwan

AU - Oh, Chang Hyun

AU - Lee, So Ha

AU - Cho, Seung Joo

AU - Sim, Tae Bo

AU - Hah, Jung Mi

AU - Kim, Dong Jin

AU - Choi, Jung Hoon

AU - Yoo, Kyung Ho

N1 - Funding Information: We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

AB - The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

KW - Aminoquinolines

KW - Antiproliferative activity

KW - Fibroblast cell line

KW - Melanoma cell line

KW - Selectivity

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VL - 19

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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