Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bong Soo Nam; Hwan Kim; Chang Hyun Oh; So Ha Lee; Seung Joo Cho; Tae Bo Sim; Jung Mi Hah; Dong Jin Kim; Jung Hoon Choi; Kyung Ho Yoo

doi:10.1016/j.bmcl.2009.05.007

Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bong Soo Nam, Hwan Kim, Chang Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung Mi Hah, Dong Jin Kim, Jung Hoon Choi, Kyung Ho Yoo

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC₅₀ = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

Original language	English
Pages (from-to)	3517-3520
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2009.05.007
Publication status	Published - 2009 Jul 1

Keywords

Aminoquinolines
Antiproliferative activity
Fibroblast cell line
Melanoma cell line
Selectivity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.05.007

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title = "Aminoquinoline derivatives with antiproliferative activity against melanoma cell line",

abstract = "The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.",

keywords = "Aminoquinolines, Antiproliferative activity, Fibroblast cell line, Melanoma cell line, Selectivity",

author = "Nam, {Bong Soo} and Hwan Kim and Oh, {Chang Hyun} and Lee, {So Ha} and Cho, {Seung Joo} and Sim, {Tae Bo} and Hah, {Jung Mi} and Kim, {Dong Jin} and Choi, {Jung Hoon} and Yoo, {Kyung Ho}",

note = "Funding Information: We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.",

year = "2009",

month = jul,

day = "1",

doi = "10.1016/j.bmcl.2009.05.007",

language = "English",

volume = "19",

pages = "3517--3520",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

AU - Nam, Bong Soo

AU - Kim, Hwan

AU - Oh, Chang Hyun

AU - Lee, So Ha

AU - Cho, Seung Joo

AU - Sim, Tae Bo

AU - Hah, Jung Mi

AU - Kim, Dong Jin

AU - Choi, Jung Hoon

AU - Yoo, Kyung Ho

N1 - Funding Information: We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

AB - The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

KW - Aminoquinolines

KW - Antiproliferative activity

KW - Fibroblast cell line

KW - Melanoma cell line

KW - Selectivity

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U2 - 10.1016/j.bmcl.2009.05.007

DO - 10.1016/j.bmcl.2009.05.007

M3 - Article

C2 - 19464887

AN - SCOPUS:66349104493

SN - 0960-894X

VL - 19

SP - 3517

EP - 3520

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Abstract

Keywords

ASJC Scopus subject areas

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