Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bong Soo Nam, Hwan Kim, Chang Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung Mi Hah, Dong Jin Kim, Jung Hoon Choi, Kyung Ho Yoo

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

    Original languageEnglish
    Pages (from-to)3517-3520
    Number of pages4
    JournalBioorganic and Medicinal Chemistry Letters
    Volume19
    Issue number13
    DOIs
    Publication statusPublished - 2009 Jul 1

    Bibliographical note

    Funding Information:
    We are grateful to the Korea Institute of Science and Technology (KIST) for financial support.

    Keywords

    • Aminoquinolines
    • Antiproliferative activity
    • Fibroblast cell line
    • Melanoma cell line
    • Selectivity

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Aminoquinoline derivatives with antiproliferative activity against melanoma cell line'. Together they form a unique fingerprint.

    Cite this