AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice

Myonghwan Kim, Eunkyu Au, Rachael Neve, Bong June Yoon

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. Here, we demonstrate that repeated cocaine injections cause increases in surface-expressed AMPA receptors in the dorsal striatum. The increased AMPAR expression is more robust in juvenile mice than in young adult mice. Furthermore, expression of the G1CT peptide, which prevents the delivery of AMPARs to the surface, attenuates the locomotor sensitization in juvenile mice. Our results strongly suggest that glutamatergic synaptic plasticity in the dorsal striatum may have an important role in behavioral sensitization to cocaine and that there may be different age-dependent control mechanisms.

    Original languageEnglish
    Pages (from-to)65-69
    Number of pages5
    JournalBiochemical and biophysical research communications
    Volume379
    Issue number1
    DOIs
    Publication statusPublished - 2009 Jan 30

    Bibliographical note

    Funding Information:
    This work was supported by a Korea Science and Engineering Foundation (KOSEF) Grant, funded by the Korean Government (MEST) (R01-2007-000-11034-0), and a Korea Research Foundation Grant, funded by the Korean Government (MOEHRD) (KRF-2007- 331-E00021).

    Copyright:
    Copyright 2009 Elsevier B.V., All rights reserved.

    Keywords

    • AMPA receptor
    • Dorsal striatum
    • Drug addiction
    • Synaptic plasticity

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice'. Together they form a unique fingerprint.

    Cite this