AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice

Myonghwan Kim; Eunkyu Au; Rachael Neve; Bong June Yoon

doi:10.1016/j.bbrc.2008.12.003

AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice

Myonghwan Kim, Eunkyu Au, Rachael Neve, Bong June Yoon

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. Here, we demonstrate that repeated cocaine injections cause increases in surface-expressed AMPA receptors in the dorsal striatum. The increased AMPAR expression is more robust in juvenile mice than in young adult mice. Furthermore, expression of the G1CT peptide, which prevents the delivery of AMPARs to the surface, attenuates the locomotor sensitization in juvenile mice. Our results strongly suggest that glutamatergic synaptic plasticity in the dorsal striatum may have an important role in behavioral sensitization to cocaine and that there may be different age-dependent control mechanisms.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Biochemical and biophysical research communications
Volume	379
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2008.12.003
Publication status	Published - 2009 Jan 30

Bibliographical note

Funding Information:
This work was supported by a Korea Science and Engineering Foundation (KOSEF) Grant, funded by the Korean Government (MEST) (R01-2007-000-11034-0), and a Korea Research Foundation Grant, funded by the Korean Government (MOEHRD) (KRF-2007- 331-E00021).

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

AMPA receptor
Dorsal striatum
Drug addiction
Synaptic plasticity

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2008.12.003

Cite this

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title = "AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice",

abstract = "Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. Here, we demonstrate that repeated cocaine injections cause increases in surface-expressed AMPA receptors in the dorsal striatum. The increased AMPAR expression is more robust in juvenile mice than in young adult mice. Furthermore, expression of the G1CT peptide, which prevents the delivery of AMPARs to the surface, attenuates the locomotor sensitization in juvenile mice. Our results strongly suggest that glutamatergic synaptic plasticity in the dorsal striatum may have an important role in behavioral sensitization to cocaine and that there may be different age-dependent control mechanisms.",

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author = "Myonghwan Kim and Eunkyu Au and Rachael Neve and Yoon, {Bong June}",

note = "Funding Information: This work was supported by a Korea Science and Engineering Foundation (KOSEF) Grant, funded by the Korean Government (MEST) (R01-2007-000-11034-0), and a Korea Research Foundation Grant, funded by the Korean Government (MOEHRD) (KRF-2007- 331-E00021). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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AU - Neve, Rachael

AU - Yoon, Bong June

N1 - Funding Information: This work was supported by a Korea Science and Engineering Foundation (KOSEF) Grant, funded by the Korean Government (MEST) (R01-2007-000-11034-0), and a Korea Research Foundation Grant, funded by the Korean Government (MOEHRD) (KRF-2007- 331-E00021). Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2009/1/30

Y1 - 2009/1/30

N2 - Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. Here, we demonstrate that repeated cocaine injections cause increases in surface-expressed AMPA receptors in the dorsal striatum. The increased AMPAR expression is more robust in juvenile mice than in young adult mice. Furthermore, expression of the G1CT peptide, which prevents the delivery of AMPARs to the surface, attenuates the locomotor sensitization in juvenile mice. Our results strongly suggest that glutamatergic synaptic plasticity in the dorsal striatum may have an important role in behavioral sensitization to cocaine and that there may be different age-dependent control mechanisms.

AB - Advances in understanding the neurobiology of addiction indicate that not only dopaminergic neurotransmissions but also glutamatergic neurotransmissions within the mesolimbic system play important roles. While the role for the nucleus accumbens (NAc) shell and core in addiction has been extensively studied, the function of the dorsal striatum is not clear. Here, we demonstrate that repeated cocaine injections cause increases in surface-expressed AMPA receptors in the dorsal striatum. The increased AMPAR expression is more robust in juvenile mice than in young adult mice. Furthermore, expression of the G1CT peptide, which prevents the delivery of AMPARs to the surface, attenuates the locomotor sensitization in juvenile mice. Our results strongly suggest that glutamatergic synaptic plasticity in the dorsal striatum may have an important role in behavioral sensitization to cocaine and that there may be different age-dependent control mechanisms.

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AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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