Amphiphilic hyaluronic acid-based nanoparticles for tumor-specific optical/MR dual imaging

Dong Eun Lee, Ah Young Kim, Hong Yeol Yoon, Ki Young Choi, Ick Chan Kwon, Seo Young Jeong, Jae Hyung Park, Kwangmeyung Kim

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    The amphiphilic hyaluronic acid-5β-cholanic acid (HA-CA) conjugates were synthesized to fabricate near-infrared fluorescence (NIRF) dye conjugated and water-dispersible SPION-encapsulated hyaluronic acid nanoparticles (HNPs) for a tumor-targeted optical and magnetic resonance (MR) dual imaging contrast agent. Notably, HNPs were preferentially accumulated in the tumor region, implying that the hydrophilic HA shells of nanoparticles allow prolonged circulation and excellent active targeting of the SPION encapsulated nanoparticles in tumor-bearing mice.

    Original languageEnglish
    Pages (from-to)10444-10447
    Number of pages4
    JournalJournal of Materials Chemistry
    Volume22
    Issue number21
    DOIs
    Publication statusPublished - 2012 Jun 7

    ASJC Scopus subject areas

    • General Chemistry
    • Materials Chemistry

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