An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors

Mingle Li; Jungryun Kim; Yunjie Xu; Jong Seung Kim

doi:10.1016/j.matt.2022.12.004

An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors

Mingle Li, Jungryun Kim, Yunjie Xu, Jong Seung Kim

Research output: Contribution to journal › Comment/debate › peer-review

2 Citations (Scopus)

Abstract

Pyroptosis has been viewed as a potential novel pathway toward tumor immunity, yet activating specific pyroptosis in tumor cells remains challenging. Recently in Nature Nanotechnology, Wang, Zhang, You, and colleagues reported a library of acid-activatable nanophotosensitizers that target distinct stages of endosome maturation, attaining tunable pyroptosis. This outstanding work may provide new insights into the creation of future nanomedicine with pyroptosis-modulating capacity for clinical applications.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Matter
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.matt.2022.12.004
Publication status	Published - 2023 Jan 4

Bibliographical note

Funding Information:
This work was supported by the Creative Research Initiatives project (Grant No. 2018R1A3B1052702 , J.S.K.) and Brain Pool Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Science, ICT (Grant No. 2020H1D3A1A02080172 , M.L.). We also gratefully thank the National Natural Science Foundation of China (Grant No. 82203050 , Y.X.) for providing financial support and basic research facilities.

Publisher Copyright:
© 2022 Elsevier Inc.

ASJC Scopus subject areas

Materials Science(all)

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10.1016/j.matt.2022.12.004

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title = "An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors",

abstract = "Pyroptosis has been viewed as a potential novel pathway toward tumor immunity, yet activating specific pyroptosis in tumor cells remains challenging. Recently in Nature Nanotechnology, Wang, Zhang, You, and colleagues reported a library of acid-activatable nanophotosensitizers that target distinct stages of endosome maturation, attaining tunable pyroptosis. This outstanding work may provide new insights into the creation of future nanomedicine with pyroptosis-modulating capacity for clinical applications.",

author = "Mingle Li and Jungryun Kim and Yunjie Xu and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by the Creative Research Initiatives project (Grant No. 2018R1A3B1052702 , J.S.K.) and Brain Pool Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Science, ICT (Grant No. 2020H1D3A1A02080172 , M.L.). We also gratefully thank the National Natural Science Foundation of China (Grant No. 82203050 , Y.X.) for providing financial support and basic research facilities. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

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doi = "10.1016/j.matt.2022.12.004",

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AU - Li, Mingle

AU - Kim, Jungryun

AU - Xu, Yunjie

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by the Creative Research Initiatives project (Grant No. 2018R1A3B1052702 , J.S.K.) and Brain Pool Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Science, ICT (Grant No. 2020H1D3A1A02080172 , M.L.). We also gratefully thank the National Natural Science Foundation of China (Grant No. 82203050 , Y.X.) for providing financial support and basic research facilities. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2023/1/4

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N2 - Pyroptosis has been viewed as a potential novel pathway toward tumor immunity, yet activating specific pyroptosis in tumor cells remains challenging. Recently in Nature Nanotechnology, Wang, Zhang, You, and colleagues reported a library of acid-activatable nanophotosensitizers that target distinct stages of endosome maturation, attaining tunable pyroptosis. This outstanding work may provide new insights into the creation of future nanomedicine with pyroptosis-modulating capacity for clinical applications.

AB - Pyroptosis has been viewed as a potential novel pathway toward tumor immunity, yet activating specific pyroptosis in tumor cells remains challenging. Recently in Nature Nanotechnology, Wang, Zhang, You, and colleagues reported a library of acid-activatable nanophotosensitizers that target distinct stages of endosome maturation, attaining tunable pyroptosis. This outstanding work may provide new insights into the creation of future nanomedicine with pyroptosis-modulating capacity for clinical applications.

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DO - 10.1016/j.matt.2022.12.004

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SN - 2590-2393

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An acid-activatable nanosensitizer library realizes tunable pyroptosis activation in tumors

Abstract

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