An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

Jaewon Kim, Jiyoung Yoo, Byungkook Kim, Kyung Woo Lee, Sunghyun Kim, Sukwon Hong, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

Abstract

An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.

Original languageEnglish
Pages (from-to)5443-5446
Number of pages4
JournalChemical Communications
Volume60
Issue number41
DOIs
Publication statusPublished - 2024 Apr 25

Bibliographical note

Publisher Copyright:
© 2024 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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