An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

Jaewon Kim; Jiyoung Yoo; Byungkook Kim; Kyung Woo Lee; Sunghyun Kim; Sukwon Hong; Jong Seung Kim

doi:10.1039/d4cc01231c

An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

Jaewon Kim, Jiyoung Yoo, Byungkook Kim, Kyung Woo Lee, Sunghyun Kim, Sukwon Hong, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.

Original language	English
Pages (from-to)	5443-5446
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	41
DOIs	https://doi.org/10.1039/d4cc01231c
Publication status	Published - 2024 Apr 25

Bibliographical note

Publisher Copyright:
© 2024 The Royal Society of Chemistry.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d4cc01231c

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abstract = "An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.",

author = "Jaewon Kim and Jiyoung Yoo and Byungkook Kim and Lee, {Kyung Woo} and Sunghyun Kim and Sukwon Hong and Kim, {Jong Seung}",

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AU - Kim, Jaewon

AU - Yoo, Jiyoung

AU - Kim, Byungkook

AU - Lee, Kyung Woo

AU - Kim, Sunghyun

AU - Hong, Sukwon

AU - Kim, Jong Seung

PY - 2024/4/25

Y1 - 2024/4/25

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AB - An AIE-based fluorescent probe was designed to evaluate peroxynitrite levels in complex biological samples. The newly synthesized hydrazone-conjugated probe fluoresces strongly in the presence of peroxynitrite. Clinically, the peroxynitrite levels can be measured in human serum and cellular mitochondria with an LOD of 6.5 nM by fluorescence imaging in vitro.

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AN - SCOPUS:85191805810

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JO - Chemical Communications

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ER -

An AIE-based fluorescent probe to detect peroxynitrite levels in human serum and its cellular imaging

Abstract

Bibliographical note

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