An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum

Dan Thi Thuy Hang; Tran Thi Hong Hanh; Chau Van Minh; Phan Van Kiem; Tran Huy Thai; Dongho Lee; Nguyen Tien Dat

doi:10.1016/j.phytol.2011.08.004

An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum

Dan Thi Thuy Hang, Tran Thi Hong Hanh, Chau Van Minh, Phan Van Kiem, Tran Huy Thai, Dongho Lee, Nguyen Tien Dat

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5α,8α-epoxy-4α,6β-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-β-d-glucopyranoside (2). Compounds 1 significantly inhibited NF-κB activity in TNF-α-stimulated HeLa cells with the IC ₅₀ of 12.4 μM.

Original language	English
Pages (from-to)	377-379
Number of pages	3
Journal	Phytochemistry Letters
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.phytol.2011.08.004
Publication status	Published - 2011 Sept

Keywords

Amorphane sesquiterpene
Asteraceae
Benzofuran
Eupatorium coelestinum
NF-κB

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2011.08.004

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title = "An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum",

abstract = "A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5α,8α-epoxy-4α,6β-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-β-d-glucopyranoside (2). Compounds 1 significantly inhibited NF-κB activity in TNF-α-stimulated HeLa cells with the IC 50 of 12.4 μM.",

keywords = "Amorphane sesquiterpene, Asteraceae, Benzofuran, Eupatorium coelestinum, NF-κB",

author = "Hang, {Dan Thi Thuy} and Hanh, {Tran Thi Hong} and {Van Minh}, Chau and {Van Kiem}, Phan and Thai, {Tran Huy} and Dongho Lee and Dat, {Nguyen Tien}",

note = "Funding Information: This work is supported by a grant from the International Foundation for Science (grant code F/4729-1 ). We thank the Institute of Chemistry, Vietnam Academy of Science and Technology for the NMR and HRMS measurements.",

year = "2011",

month = sep,

doi = "10.1016/j.phytol.2011.08.004",

language = "English",

volume = "4",

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journal = "Phytochemistry Letters",

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AU - Hang, Dan Thi Thuy

AU - Hanh, Tran Thi Hong

AU - Van Minh, Chau

AU - Van Kiem, Phan

AU - Thai, Tran Huy

AU - Lee, Dongho

AU - Dat, Nguyen Tien

N1 - Funding Information: This work is supported by a grant from the International Foundation for Science (grant code F/4729-1 ). We thank the Institute of Chemistry, Vietnam Academy of Science and Technology for the NMR and HRMS measurements.

PY - 2011/9

Y1 - 2011/9

N2 - A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5α,8α-epoxy-4α,6β-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-β-d-glucopyranoside (2). Compounds 1 significantly inhibited NF-κB activity in TNF-α-stimulated HeLa cells with the IC 50 of 12.4 μM.

AB - A phytochemical investigation of the aerial parts of Eupatorium coelestinum led to the isolation of an amorphane sesquiterpene and a benzofuran glucoside. By means of spectroscopic methods, their structures were determined as 5α,8α-epoxy-4α,6β-dihydroxyamorphan-2-one (1) and 2R*,3S*-toxol-7-O-β-d-glucopyranoside (2). Compounds 1 significantly inhibited NF-κB activity in TNF-α-stimulated HeLa cells with the IC 50 of 12.4 μM.

KW - Amorphane sesquiterpene

KW - Asteraceae

KW - Benzofuran

KW - Eupatorium coelestinum

KW - NF-κB

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U2 - 10.1016/j.phytol.2011.08.004

DO - 10.1016/j.phytol.2011.08.004

M3 - Article

AN - SCOPUS:84860404039

SN - 1874-3900

VL - 4

SP - 377

EP - 379

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 3

ER -

An amorphane sesquiterpene and a benzofuran glucoside from Eupatorium coelestinum

Abstract

Keywords

ASJC Scopus subject areas

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