Enantiomerically pure (1S,3S)- and (1S,3R)-1-amino-3-(hydroxymethyl) cyclopentanes have been efficiently synthesized from L-aspartic acid. The title compounds are isosteres of ribose and may be used to construct nucleoside analogs with important antiviral and antineoplastic activities as demonstrated by a concise total synthesis of (+)-4′-deoxycarbapentostatin nucleoside.
|Number of pages||4|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 2003 Oct|
- Amino acid
ASJC Scopus subject areas
- Drug Discovery