An electrostatic micromechanical biosensor for electrical detection of label-free DNA

Ji Min Choi; Sung Up Hwang; Chang Hoon Kim; Hyun Ho Yang; Cheulhee Jung; Hyun Gyu Park; Jun Bo Yoon; Yang Kyu Choi

doi:10.1063/1.3703764

An electrostatic micromechanical biosensor for electrical detection of label-free DNA

Ji Min Choi, Sung Up Hwang, Chang Hoon Kim, Hyun Ho Yang, Cheulhee Jung, Hyun Gyu Park, Jun Bo Yoon, Yang Kyu Choi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V _PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.

Original language	English
Article number	163701
Journal	Applied Physics Letters
Volume	100
Issue number	16
DOIs	https://doi.org/10.1063/1.3703764
Publication status	Published - 2012 Apr 16
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the National Research and Development Program (NRDP, 2011-0002182) for the development of biomedical function monitoring biosensors and a grant from the National Research Foundation of Korea (NRF) funded by the Korean Ministry of Education, Science and Technology (MEST) (No. 2011-0020487). This work was also supported by the Smart IT Convergence System Research Center funded by the MEST (SIRC-2011-0031845).

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.3703764

Cite this

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title = "An electrostatic micromechanical biosensor for electrical detection of label-free DNA",

abstract = "An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.",

author = "Choi, {Ji Min} and Hwang, {Sung Up} and Kim, {Chang Hoon} and Yang, {Hyun Ho} and Cheulhee Jung and {Gyu Park}, Hyun and Yoon, {Jun Bo} and Choi, {Yang Kyu}",

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AU - Choi, Ji Min

AU - Hwang, Sung Up

AU - Kim, Chang Hoon

AU - Yang, Hyun Ho

AU - Jung, Cheulhee

AU - Gyu Park, Hyun

AU - Yoon, Jun Bo

AU - Choi, Yang Kyu

N1 - Funding Information: This research was supported by the National Research and Development Program (NRDP, 2011-0002182) for the development of biomedical function monitoring biosensors and a grant from the National Research Foundation of Korea (NRF) funded by the Korean Ministry of Education, Science and Technology (MEST) (No. 2011-0020487). This work was also supported by the Smart IT Convergence System Research Center funded by the MEST (SIRC-2011-0031845).

PY - 2012/4/16

Y1 - 2012/4/16

N2 - An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.

AB - An electrostatic micromechanical biosensor is demonstrated for the label-free electrical detection of DNA, based on electrostatic actuation of a double-clamped micromechanical cantilever by driving gate electrodes to establish a current path through drain and source electrodes. Intrinsic charges in DNA alter surface charges on the gate by pre-charging concept and change the pull-in voltage (V PI), the voltage required to bring the suspended cantilever into contact with the drain electrode by induced electrostatic force. Its operation principle is verified by a numerical simulation and a capacitive model. The proposed biosensor represents a breakthrough for practical exploitation of electro-mechanical based sensors.

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An electrostatic micromechanical biosensor for electrical detection of label-free DNA

Abstract

Bibliographical note

ASJC Scopus subject areas

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